Mayo Clinic Laboratory and pathology research roundup: November 22
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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.
Featured Abstract
Progression of chronic kidney disease following radical and partial nephrectomy
To compare renal functional outcomes, as determined by percent decline in estimated glomerular filtration rate (eGFR) and CKD stage progression following radical (RN) and partial nephrectomy (PN) stratified by preoperative CKD stage. We retrospectively evaluated adults treated with RN or PN between 1980 and 2018 for unilateral, sporadic, solid renal masses.Percent change in eGFR at 1 year was significantly worse for RN (n = 1724; 57%) compared with PN (n = 1322; 43%) for all preoperative CKD stages. RN was more likely to result in decline in eGFR and CKD stage progression compared to PN for patients with preoperative CKD stage IIIb or less.
Published to PubMed This Week
- Glucocorticoids mediate transcriptome-wide alternative polyadenylation: potential mechanistic and clinical implications
Clinical and translational science, 15 - Immune cells are increased in normal breast tissues of BRCA1/2 mutation carriers
Breast cancer research and treatment - Chylous ascites: reassessment of diagnostic criteria in patients with portal hypertension
The American journal of gastroenterology - Drug testing in support of the diagnosis of neonatal abstinence syndrome: the current situation
Clinical biochemistry - Comparison of intact protein and digested peptide techniques for high throughput proteotyping of ApoE
Clinical proteomics, 19 - Pharmacologic treatment of delirium symptoms: A systematic review
General hospital psychiatry, 79 - Reproductive risk factors associated with breast cancer in young women by molecular subtype
Breast (Edinburgh, Scotland), 66 - Alternative lengthening of telomeres in primary hepatic neoplasms
Human pathology - Author Reply
Urology, 169 - Mutations of FH and IDH may induce gliomagenesis by similar mechanisms
Journal of neuropathology and experimental neurology - Neuropathological findings in COVID-19: an autopsy cohort
Journal of neuropathology and experimental neurology - Sebaceous carcinoma of the eyelid: proposed nomenclature for multifocal and multicentric disease
Ophthalmic plastic and reconstructive surgery - Clinical use of a 16S ribosomal RNA gene-based sanger and/or next generation sequencing assay to test preoperative synovial fluid for periprosthetic joint infection diagnosis
mBio - Emerging innovations for lumbar spondylolisthesis management: a systematic review of active and prospective clinical trials
Neurosurgical review, 45
