Mayo Clinic Laboratory and pathology research roundup: November 29
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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.
Featured Abstract
AMPK: The key to ischemia-reperfusion injury
Ischemia-reperfusion injury (IRI) refers to a syndrome in which tissue damage is further aggravated and organ function further deteriorates when blood flow is restored after a period of tissue ischemia. Acute myocardial infarction, stress ulcer, pancreatitis, intestinal ischemia, intermittent claudication, acute tubular necrosis, postshock liver failure, and multisystem organ failure are all related to reperfusion injury. AMP-activated protein kinase (AMPK) has been identified in multiple catabolic and anabolic signaling pathways.
Published to PubMed This Week
- Optical genome mapping in acute myeloid leukemia: a multicenter evaluation
Blood advances - Utility of disc space aspirate cell counts and differentials in the diagnosis of native vertebral osteomyelitis
Journal of bone and joint infection, 7 - The risk of coronavirus disease 2019 (COVID-19) among individuals with monoclonal B cell lymphocytosis
Blood cancer journal, 12 - Description, validation, and review of a decade of experience with a laboratory-developed PCR test for detection of Mycobacterium tuberculosis complex in pulmonary and extrapulmonary specimens
Journal of clinical tuberculosis and other mycobacterial diseases, 29 - Metastatic melanoma involving a genetically confirmed angiofibroma of soft tissue: a previously unreported type of tumor-to-tumor metastasis
Journal of cutaneous pathology - Video commentary & machine learning: tell me what you see, I tell you who you are
Journal of surgical education, 79 - Simulation as soothsayer: simulated surgical skills MMIs during residency interviews are associated with first year residency performance
Journal of surgical education, 79 - Course design and learning outcomes of a practical online ergonomics course for surgical residents
Journal of surgical education, 79 - Problems and solutions: a special issue of gastrointestinal, pancreatic, and liver pathology
Human pathology, 129 - Primary leptomeningeal lymphoma: clinicopathologic features of 2 rare phenotypes
Journal of neuropathology and experimental neurology, 81 - Lessons from histopathologic examination of nephrectomy specimens in patients with tuberous sclerosis complex: cysts, angiomyolipomas, and renal cell carcinoma
Human pathology, 129 - Therapeutic plasma exchange for steroid refractory idiopathic inflammatory myopathies with interstitial lung disease
Journal of clinical apheresis - Myocarditis and endomyocardial biopsy: achieving consensus diagnosis on hundred cases
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology, 62 - Comparison of the BioFire joint infection panel to 16S ribosomal RNA gene-based targeted metagenomic sequencing for testing synovial fluid from patients with knee arthroplasty failure
Journal of clinical microbiology - Genetic therapy in a mitochondrial disease model suggests a critical role for liver dysfunction in mortality
eLife, 11 - Glucocorticoids unmask silent non-coding genetic risk variants for common diseases
Nucleic acids research - Development and evaluation of a core genome multilocus sequencing typing (cgMLST) scheme for serratia marcescens molecular surveillance and outbreak investigations
Journal of clinical microbiology, 60 - Reduced intensity conditioning allogeneic hematopoietic stem cell transplantation in VEXAS syndrome: data from a prospective series of patients
American journal of hematology - Malignant left ventricular outflow tract obstruction: a reason to operate?
JACC. Case reports, 4 - Distinctive nested glomoid neoplasm: clinicopathologic analysis of 20 cases of a mesenchymal neoplasm with frequent GLI1 alterations and indolent behavior
The American journal of surgical pathology - Diarrhea, colonic stenoses and a kinase inhibitor
Gastroenterology - Changes in glomerular volume, sclerosis, and ischemia at 5 years after kidney transplantation: incidence and correlation with late graft failure
Journal of the American Society of Nephrology : JASN - Hybrid tumors with perineurioma components: a systematic review of the literature and illustrative case
Acta neurochirurgica - Targeted metagenomic sequencing-based approach applied to 2146 tissue and body fluid samples in routine clinical practice
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 75
