Mayo Clinic Laboratory and pathology research roundup: December 27
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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.
Featured Abstract
Neuropathological findings in COVID-19: an autopsy cohort
The literature regarding the neuropathological findings in cases of SARS-CoV-2 infection, which causes coronavirus disease 2019 (COVID-19), is expanding. We identified 72 patients who died of COVID-19 (n = 48) or had recovered shortly before death (n = 24) and had autopsies performed at our institution (49 males, 23 females; median age at death 76.4 years, range: 0.0-95.0 years). Droplet digital polymerase chain reaction (ddPCR) for the detection of SARS-CoV-2 was performed (n = 58) in multiple brain regions.
Published to PubMed This Week
- Niche-mediated repair of airways is directed in an occupant-dependent manner
Cell reports, 41 - H3 G34 mutation assessment for diffuse gliomas in adults: when would testing be most diagnostically useful?
Journal of neuropathology and experimental neurology, 82 - Mutations of FH and IDH may induce gliomagenesis by similar mechanisms
Journal of neuropathology and experimental neurology, 82 - Small cell transformation in a patient with RET fusion-positive lung adenocarcinoma on pralsetinib
JCO precision oncology, 69 - Durable response seen in patients with refractory fistulizing perianal Crohn's disease using autologous mesenchymal stem cells on a dissolvable matrix: results from the phase I stem cell on matrix plug (STOMP) trial
Diseases of the colon and rectum - Artificial intelligence-augmented electrocardiography for left ventricular systolic dysfunction in patients undergoing high-sensitivity cardiac troponin T
Acute cardiovascular care - ACE2 and TMPRSS2 SARS-CoV-2 infectivity genes: deep mutational scanning and characterization of missense variants
Human molecular genetics, 31 - Distal radius fracture treatment outcomes in patients with ipsilateral hemiplegia or hemiparesis
Hand - Outcomes after treatment with cobimetinib in patients with rosai-dorfman disease based on KRAS and MEK alteration status
JAMA oncology, 8 - Financial hardship in breast cancer survivors: a prospective analysis of change in financial concerns over time
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 31 - Liquid chromatography-tandem mass spectrometry for clinical diagnostics
Nature reviews. Methods primers, 2 - Expanding the platelet inventory to mitigate the impact of severe shortages
American Society of Hematology. Education Program, 2022 - Characterizing M-protein light chain glycosylation via mass spectrometry
Clinical biochemistry, 109-110 - Maintenance of remission and risk of relapse in myeloperoxidase positive antineutrophil cytoplasmic antibody-associated vasculitis with kidney involvement
Clinical journal of the American Society of Nephrology : CJASN - Culture media composition influences patient-derived organoid ability to predict therapeutic responses in gastrointestinal cancers
JCI insight, 7 - Glucocorticoids unmask silent non-coding genetic risk variants for common diseases
Nucleic acids research, 50 - Changes in all-cause and cause-specific mortality during the first year of the COVID-19 pandemic in Minnesota: population-based study
BMC public health, 22 - Research opportunities in the treatment of mitral valve prolapse: JACC expert panel
Journal of the American College of Cardiology, 80 - Dataset for the reporting of neoplasms of the heart, pericardium, and great vessels: recommendations from the International Collaboration on Cancer Reporting (ICCR)
Virchows Archiv : an international journal of pathology - An amelanotic choroidal lesion in a 68-year-old man
JAMA ophthalmology - Predictors of response to venetoclax plus hypomethylating agent therapy and survival in blast-phase myeloproliferative neoplasm
Haematologica - Acute symptomatic seizures secondary to myelin oligodendrocyte glycoprotein antibody-associated disease
Epilepsia, 63 - R2 advances in robotic-assisted spine surgery: comparative analysis of options, future directions, and bibliometric analysis of the literature
Neurosurgical review, 46
