Mayo Clinic Laboratory and pathology research roundup: January 17

By Samantha Rossi • January 17, 2023

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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

Exploring gene expression profiles in primary central nervous system vasculitis

This study was undertaken to explore the gene expression profile of primary central nervous system vasculitis (PCNSV). Brain specimens of 4 patients with granulomatous vasculitis (GV), 5 with lymphocytic vasculitis (LV), 4 with amyloid β-related angiitis (ABRA), and 4 normal controls were studied. RNA-sequencing was performed using the Illumina Hiseq-4,000 platform and the Illumina TruSeq Total-RNA library. Transcripts differentially expressed between PCNSV and normal brain indicated that endosomal, mitochondrial, and ribosome dysfunction, alterations in protein synthesis, and noncoding RNAs might be involved in PCNSV. 

Read more.

Published to PubMed This Week

• Type 2 myocardial infarction: do we need risk scores?
  Journal of the American College of Cardiology, 81
• Autoimmune encephalitis misdiagnosis in adults
  JAMA neurology, 80
• A phase II study of combination daunorubicin, cytarabine (Ara-c) and nilotinib (TAsigna) (DATA) in patients newly diagnosed with acute myeloid leukemia with KIT expression
  American journal of hematology
• Monoclonal gammopathy of thrombotic/thrombocytopenic significance
  Blood
• Intact fibroblast growth factor 23 (iFGF23) concentrations in hypophosphatemic disorders
  Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
• Evaluation of the cost-effectiveness of surgical treatment options for benign prostatic hyperplasia
  Urology
• Immune cells are increased in normal breast tissues of BRCA1/2 mutation carriers
  Breast cancer research and treatment, 197
• Authors' reply to: "neuropathologic findings in COVID-19 patients should be correlated with clinical neurologic abnormalities"
  Journal of neuropathology and experimental neurology
• Translational significance of CDKN2A/B homozygous deletion in isocitrate dehydrogenase-mutant astrocytoma
  Neuro-oncology, 25
• A TRIP11: FLT3 gene fusion in a patient with myeloid/lymphoid neoplasm with eosinophilia and tyrosine kinase gene fusions: a case report and review of the literature
  Cold Spring Harbor molecular case studies
• Underestimation of aortic stenosis severity by doppler mean gradient during atrial fibrillation: insights from aortic valve weight
  Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, 36
• Contralateral breast cancer risk among carriers of germline pathogenic variants in ATM, BRCA1, BRCA2, CHEK2, and PALB2
  Journal of clinical oncology : official journal of the American Society of Clinical Oncology
• AMPAR autoimmunity: neurological and oncological accompaniments and co-existing neural autoantibodies
  Journal of neuroimmunology, 375
• Sonicate fluid cellularity predicted by transcriptomic deconvolution differentiates infectious from non-infectious arthroplasty failure
  The Journal of bone and joint surgery. American volume, 105
• 30-day morbidity and mortality after transoral robotic surgery for human papillomavirus (HPV) associated oropharyngeal squamous cell carcinoma: a retrospective analysis of two prospective adjuvant de-escalation trials (MC1273 & MC1675)
  Oral oncology, 137
• Mesenchymal neoplasm with ACTB-GLI1 fusion in an individual with neurofibromatosis type 1
  Mayo Clinic proceedings, 98
• Bone turnover markers to monitor oral bisphosphonate therapy
  Cleveland Clinic journal of medicine, 90
  

Samantha Rossi

Samantha Rossi is a Digital Marketing Manager at Mayo Clinic Laboratories. She supports marketing strategies for product management and specialty testing. Samantha has worked at Mayo Clinic since 2019.