Mayo Clinic Laboratory and pathology research roundup: January 24
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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.
Featured Abstract
Automated scoring of total inflammation in renal allograft biopsies
Computer-assisted scoring is gaining prominence in the evaluation of renal histology; however, much of the focus has been on identifying larger objects such as glomeruli. Total inflammation impacts graft outcome, and its quantification requires tools to identify objects at the cellular level or smaller. Sixty renal transplant whole slide images were used for digital image analysis. Multiple thresholding methods using pixel intensity and object size were used to identify inflammation in the cortex. Automated scoring of inflammation showed a high correlation with Banff scoring. Digital image analysis provides a powerful tool for analysis of renal pathology, not only because it is reproducible and can be automated, but also because it provides much more granular data for studies.
Published to PubMed This Week
- Periprosthetic joint infection
The New England journal of medicine, 388 - Adequacy of cefepime concentrations in the early phase of critical illness: a case for precision pharmacotherapy
Pharmacotherapy - Does metabolite matter? Defining target itraconazole and hydroxy-itraconazole serum concentrations for blastomycosis
Mycoses - GFR estimated with creatinine rather than cystatin C is more reflective of the true risk of adverse outcomes with low GFR in kidney transplant recipients
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - Type 2 myocardial infarction: do we need risk scores?
Journal of the American College of Cardiology, 81 - Biomarkers for immune checkpoint inhibitor-induced myocarditis: caution needed
JACC. CardioOncology, 4 - Cardiac troponin measurement at the point of care: educational recommendations on analytical and clinical aspects by the IFCC Committee on Clinical Applications of Cardiac Bio-Markers (IFCC C-CB)
Clinical chemistry and laboratory medicine - Noninvasive diagnosis of PLA2R-associated membranous nephropathy: a validation study
Clinical journal of the American Society of Nephrology : CJASN, 16 - Prognostic implications of a morphometric evaluation for chronic changes on all diagnostic native kidney biopsies
Journal of the American Society of Nephrology : JASN, 33 - SETDB1 modulates degradation of phosphorylated RB and anti-cancer efficacy of CDK4/6 inhibitors
Cancer research - Alternative lengthening of telomeres in primary hepatic neoplasms
Human pathology, 131 - Genetic and immunohistochemical profiling of NK/T-cell lymphomas reveals prognostically relevant BCOR-MYC association
Blood advances, 7 - Large B-cell lymphoma with IRF4 gene rearrangements: differences in clinicopathologic, immunophenotypic and cytogenetic features between pediatric and adult patients
Human pathology, 131
