Mayo Clinic Laboratory and pathology research roundup: February 15
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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.
Featured Abstract
Activity of a hypochlorous acid-producing electrochemical bandage as assessed with a porcine explant biofilm model
The activity of a hypochlorous acid-producing electrochemical bandage (e-bandage) in preventing methicillin-resistant Staphylococcus aureus infection (MRSA) infection and removing biofilms formed by MRSA was assessed using a porcine explant biofilm model. e-Bandages inhibited S. aureus infection (p = 0.029) after 12 h (h) of exposure and reduced 3-day biofilm viable cell counts after 6, 12, and 24 h exposures (p = 0.029). Needle-type microelectrodes were used to assess HOCl concentrations in explant tissue as a result of e-bandage treatment; toxicity associated with e-bandage treatment was evaluated. HOCl concentrations in infected and uninfected explant tissue varied between 30 and 80 µM, decreasing with increasing distance from the e-bandage. Eukaryotic cell viability was reduced by an average of 71% and 65% in fresh and day 3-old explants, respectively, when compared to explants exposed to nonpolarized e-bandages. HOCl e-bandages are a promising technology that can be further developed as an antibiotic-free treatment for wound biofilm infections.
Published to PubMed This Week
- Changes in Glomerular volume, Sclerosis, and Ischemia at 5 years after kidney transplantation: incidence and correlation with late graft failure
Journal of the American society of Nephrology - AMPAR autoimmunity: Neurological and oncological accompaniments and co-existing neural autoantibodies
Journal of Neuroimmunology - Chylous Ascites: reassessment of diagnostic criteria in patients with portal hypertension
American Journal of Gastroenterology - Population-based evaluation of total protein in cerebrospinal fluid
Mayo Clinic Proceedings - Primary neuroendocrine tumors and primary neuroendocrine carcinomas of the liver: a proposal for a multidiscipline definition
Human Pathology - Microscopic colitis: lymphocytic colitis, collagenous colitis, and beyond
Human Pathology - Histologic evaluation in the diagnosis and management of celiac disease: practical challenges, current best practice recommendations and beyond
Human Pathology - Single patch super-resolution of histopathology whole slide images: a comparative study
Journal of Medical Imaging - Antibody-based therapeutics for the treatment of renal cell Carcinoma: challenges and opportunities
Oncologist - Adrenal Epithelial cysts
Mayo Clinic Proceedings - Population-based evaluation of total protein in cerebrospinal fluid
Mayo Clinic Proceedings
