Molecular biomarkers are a critical component in the treatment of adult and pediatric brain tumors. In this test-specific episode of the "Answers From the Lab" podcast, Robert Jenkins, M.D., Ph.D., explains how Mayo Clinic Laboratories' chromosomal microarray provides more comprehensive and accurate tumor analysis compared with other test methods.

"The array test covers all the possibilities," Dr. Jenkins says. "It easily finds the various mutations that are essential for diagnosis and prognosis."

He notes that the chromosomal microarray is more accurate than fluorescence in situ hybridization (FISH), and requires less tumor content than methylation assay.

Each microarray is analyzed by an experienced Mayo Clinic pathologist. "We use our specialist knowledge about brain tumors and what we see in the microarray to generate a meaningful report that can guide a care plan for these complex brain tumors," Dr. Jenkins says.

Listen to learn more about Mayo Clinic Laboratories' chromosomal microarray assay.

Note: Podcasts will not playback on Internet Explorer. Please use an alternative web browser, or listen from your mobile device on a preferred listening app.

Testing

CMAPT | Chromosomal Microarray, Tumor, Formalin-Fixed Paraffin-Embedded

Useful information

• Genomic characterization of tumor for copy number imbalances and loss of heterozygosity.
• Assisting in the diagnosis and classification of malignant neoplasms.
• Evaluating the prognosis for patients with malignant tumors.

Specimen requirements

Specimen Required (submit only 1 of the following specimens):

• Specimen Type: Tissue
• Container/Tube: Formalin-fixed, paraffin-embedded tumor tissue block.

• Specimen Type: Slides
• Container/Tube: 10 Consecutive, unstained, 5-micron-thick sections placed on positively charged slides and 1 hematoxylin and eosin-stained slide.

Ordering Guidance: This test is not performed on fresh tissue specimens. If testing is needed for fresh tissue specimens, order CMAT / Chromosomal Microarray, Tumor, Fresh or Frozen using Affymetrix Cytoscan HD.

Necessary Information: A reason for testing and pathology report are required for testing to be performed. Send information with specimen. Acceptable pathology reports include working drafts, preliminary pathology or surgical pathology reports.

Performance information

Analytic time: 10 to 21 days

Days performed: Monday through Friday

The latest

Comprehensive Genetic Test Guides Prescribing of a Transplant Anti-Rejection Drug: Jessica Wright, Pharm.D., BCACP

April 8, 2025

Jessica Wright, Pharm.D., BCACP, explains how Mayo Clinic Laboratories' 3A5Q test helps determine initial tacrolimus doses for individuals after non-liver organ transplants. Optimal tacrolimus levels are one of the important factors in survival of the transplanted organ.

Assay identifies most known membranous nephropathy antigens: Sanjeev Sethi, M.D., Ph.D.

January 21, 2025

Sanjeev Sethi, M.D., Ph.D., explains how Mayo Clinic Laboratories' new mass spectrometry test (Mayo ID: MSMN) identifies most antigens now known to cause membranous nephropathy. Precise identification of antigens is important for optimal management of this serious kidney disease.

Unique Test Screens for Recently Identified Peripheral Neuropathy: Matthew Schultz, Ph.D., and Amy White, M.S., CGC

September 24, 2024

Matthew J. Schultz, Ph.D., and Amy L. White, M.S., CGC, explain how Mayo Clinic Laboratories' unique urine assay (Mayo ID: SORD) screens for peripheral neuropathy arising from SORD gene variants. Although recently identified, SORD-related peripheral neuropathy is fairly common.

View MoreView Less