Mayo Clinic Laboratory and pathology research roundup: April 18

By Samantha Rossi • April 18, 2023

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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

Renal involvement in systemic sclerosis

Systemic sclerosis is a rare autoimmune vasculopathy associated with dysregulated innate and adaptive immunity that leads to generalized systemic fibrosis. Renal involvement occurs in a significant proportion of systemic sclerosis patients, and is associated with worse outcome. Scleroderma renal crisis (SRC) is the most studied and feared renal complication described in systemic sclerosis. However, with the emergence of ACE inhibitors and better management, the mortality rate of SRC has significantly decreased. Renal disease in systemic sclerosis offers a wide array of differential diagnoses that may be challenging for the clinician. 

Read more.

Published to PubMed This Week

• Collection and processing of hematopoietic progenitor cell products at risk of presenting with cold agglutination.
  Cytotherapy
• Associations of neurodegeneration biomarkers in cerebrospinal fluid with markers of alzheimer's disease and vascular pathology.
  Journal of Alzheimer's Disease
• Perineurioma of the sciatic nerve with reticular, microcystic, and pseudolipoblastic features: Illustrative case.
  Journal of neurosurgery. Case lessons.
• TP53 mutation variant allele frequency of ≥10% is associated with poor prognosis in therapy-related myeloid neoplasms.
  Blood Cancer Journal
• Massive transfusion protocol: What's in a name?
  Transfusion
• Neoadjuvant therapy regimens for hilar cholangiocarcinoma before liver transplant.
  American Journal of Clinical Oncology
• What's in your water? A well-known risk for arsenic toxicity.
  Journal of Rural Medicine
• Diagnosis and prognosis of type 2 myocardial infarction using objective evidence of acute myocardial ischemia: a validation study.
  American Journal of Medicine
• Observation and treatment in DDX41-mutated acute myeloid leukemia and myelodysplastic syndrome.
  Blood Cancer Journal
  

Samantha Rossi

Samantha Rossi is a Digital Marketing Manager at Mayo Clinic Laboratories. She supports marketing strategies for product management and specialty testing. Samantha has worked at Mayo Clinic since 2019.