Mayo Clinic Laboratory and Pathology Research Roundup: December 26

By Sarah Jarvis • December 26, 2023

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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

Detection of Histoplasma capsulatum and Blastomyces dermatitidis antigens in serum using a single quantitative enzyme immunoassay.

Histoplasma and Blastomyces antigen detection assays are commonly used diagnostic tools. However, a high level of cross-reactivity between these antigens prevents definitive pathogen identification by these assays alone. Retrospective analysis of 3,529 patients with Histoplasma and Blastomyces antigen testing performed on the same serum sample yielded an overall percent agreement of 99.3% (3,506 of 3,529; kappa: 0.859) between the two assays, suggesting that use of a single assay to detect both antigens may be an alternative diagnostic approach. We assessed performance of the Gotham BioTech Blastomyces antigen (GBA) enzyme immunoassay (EIA) (Portland, Maine) for detection of Blastomyces and Histoplasma antigens in serum.

Read more.

Published to PubMed This Week

• Impact of various estimated glomerular filtration rate equations on the pharmacokinetics of meropenem in critically Ill adults.
  Critical Care Explorations
• Population pharmacokinetic model of cefepime for critically ill adults: a comparative assessment of eGFR equations.
  Antimicrobial Agents and Chemotherapy
• Updates in the classification of T-cell lymphomas and Lymphoproliferative disorders.
  Current Hematologic Malignancy Reports
• Ethical and legal obligations for fesearch involving pregnant persons in a post-Dobbs context.
  The Journal of Law, Medicine, & Ethics
• Characteristics of Lambl excrescences of aortic and pulmonary valves in healthy hearts.
  Cardiovascular Pathology
• A systematic review of clozapine-associated inflammation and related monitoring.
  Pharmacotherapy
• Benefits and challenges of remote patient monitoring as perceived by health care practitioners: A dystematic review.
  The Permanente Journal
• Clinical utility of a cytomegalovirus-specific T cell assay in assessing the risk of post-prophylaxis cytomegalovirus infection and post-treatment relapse.
  Clinical Transplantation
• SARS-CoV-2 emergency use authorization published sensitivity differences do not correlate with positivity rate in a hospital/reference laboratory setting.
  Diagnostic Microbiology and Infectious Disease
• The role of artificial intelligence for providing scientific content for laboratory medicine.
  The Journal of Applied Laboratory Medicine
• Analysis of vitamin D₃-sulfate and 25-hydroxyvitamin D₃-sulfate in breastmilk by LC-MS/MS.
  Journal of Chromatography
• Dual AApoAIV amyloidosis and ATTR amyloidosis arising in the same patient: a report of three cases.
  Amyloid
• Alpha-1-Antitrypsin (A1AT) proteotyping by LC-MS/MS.
  Methods in Molecular Biology
• Unraveling the genomic underpinnings of unbalanced MYC break-apart FISH results using whole genome sequencing analysis.
  Blood Cancer Journal
• Cold platelet transfusion: The effects of a fluid warmer on platelet function.
  Transfusion
• Correlation of PRAME immunohistochemistry with PRAME status on gene expression profiling in enucleated uveal melanoma.
  Canadian Journal of Ophthalmology
• Detection and quantification of Babesia species intraerythrocytic parasites by flow cytometry.
  American Journal of Clinical Pathology
• Interlaboratory comparison of Pseudomonas aeruginosa phage susceptibility testing.
  Journal of Clinical Microbiology
• Open invitation to contribute ideas to a multifaceted approach to ethics in xenotransplantation.
  Xenotransplantation
• The spectrum of endocrine pathology.
  Endocrine Pathology
• Primary and specialist palliative care in neurosurgery: A narrative review and bibliometric analysis of blioblastoma and stroke.
  World Neurosurgery

Sarah Jarvis

Sarah Jarvis is a Senior Marketing Specialist at Mayo Clinic Laboratories. She supports marketing strategies for paid media.