Mayo Clinic Laboratory and Pathology Research Roundup: February 13

By Sarah Jarvis • February 13, 2024

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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

Venous and arterial thrombosis in patients with VEXAS syndrome.

VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) syndrome, caused by somatic mutations in UBA1, is an autoinflammatory disorder with diverse systemic manifestations. Thrombosis is a prominent clinical feature of VEXAS. The risks factors and frequency of thrombosis in VEXAS are not well described, due to the disease's new discovery and paucity of large databases. We evaluated 119 VEXAS patients for venous and arterial thrombosis and correlated their presence with clinical outcomes and survival.

Read more.

Published to PubMed This Week

• A case-control autopsy series of liver pathology associated with novel coronavirus disease (COVID-19).
  Annals of Diagnostic Pathology
• Genetic landscape and clinical outcomes of patients with BCOR mutated myeloid neoplasms.
  Haematologica
• Performance of the Lumipulse plasma Aβ42/40 and pTau181 immunoassays in the detection of amyloid pathology.
  Alzheimers & Dementia
• New insights into neuropathology and pathogenesis of autoimmune glial fibrillary acidic protein meningoencephalomyelitis.
  Acta Neuropathologica
• Clinicopathologic characteristics, etiologies, and outcome of secondary oxalate nephropathy.
  Mayo Clinic Proceedings
• Sporadic prostate cancer in a patient with Lynch syndrome.
  Mayo Clinic Proceedings
• Breast cancer polygenic-risk score influence on risk-reducing endocrine therapy use: Genetic risk estimate (GENRE) trial 1-year and 2-year follow-up.
  Cancer Prevention Research
• Diagnostic performance of a fecal Calprotectin assay as a biomarker for Mayo endoscopic subscore in ulcerative colitis: Result from a tertiary referral center.
  Inflammatory Bowel Diseases
• International reproducibility study of thymic epithelial tumors staging: pT stage is an issue. proposals for improvement. A RYTHMIC/ITMIG study.
  Lung Cancer
• Advanced systemic mastocytosis-Revised classification, new drugs and how we treat.
  British Journal of Haematology
• HOCl-producing electrochemical bandage for treating Pseudomonas aeruginosa-infected murine wounds.
  Antimicrobial Agents and Chemotherapy
• Case Report: A myxoma with a far reach.
  Frontiers in Cardiovascular Medicine
• [Summary: International consensus statement on nomenclature and classification of the congenital bicuspid aortic valve and its aortopathy, for clinical, surgical, interventional and research purposes].
  Archivos de Cardiologia de Mexico
• The effect of implant density on adolescent idiopathic scoliosis fusion: Results of the minimize implants maximize outcomes randomized clinical trial.
  The Journal of Bone and Joint Surgery
• Imaging of alcohol-associated liver disease.
  American Journal of Roentgenology
• Laboratorian interpretation of drug testing results in pain management: Lessons from College of American Pathologists proficiency testing.
  Archives of Pathology and Laboratory Medicine
• Assessment of sigma error metrics associated with manual secondary result review and subsequent artificial intelligence-driven quality assurance review-application to kidney stone analysis.
  Clinical Chemistry

Sarah Jarvis

Sarah Jarvis is a Senior Marketing Specialist at Mayo Clinic Laboratories. She supports marketing strategies for paid media.