Mayo Clinic Laboratory and Pathology Research Roundup: February 27

By Sarah Jarvis • February 27, 2024

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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

Neoadjuvant cobimetinib and atezolizumab with or without vemurafenib for high-risk operable Stage III melanoma: the Phase II NeoACTIVATE trial.

Both targeted therapies and immunotherapies provide benefit in resected Stage III melanoma. We hypothesized that the combination of targeted and immunotherapy given prior to therapeutic lymph node dissection (TLND) would be tolerable and drive robust pathologic responses. 

Read more.

Published to PubMed This Week

• The Brief Case: Dirofilaria species causing a subcutaneous nodule after a visit to the beach in Florida.
  Journal of Clinical Microbiology
• Testing for Helicobacter pylori in an era of antimicrobial resistance.
  Journal of Clinical Microbiology
• Vascular tumors of intermediate malignancy: An update.
  Human Pathology
• Imprecision of high-sensitivity cardiac troponin assays at the female 99th-percentile.
  Clinical Biochemistry
• Surface-modified measles vaccines encoding oligomeric, prefusion-stabilized SARS-CoV-2 spike glycoproteins boost neutralizing antibody responses to Omicron and historical variants, independent of measles seropositivity.
  mBio
• Tumor mutational load is prognostic for progression to therapy among high-count monoclonal B-cell lymphocytosis (HCMBL).
  Blood Advances
• Vertical transmission of SARS-CoV-2-specific antibodies and cytokine profiles in pregnancy.
  The Journal of Infectious Diseases
• GAiN: An integrative tool utilizing generative adversarial neural networks for augmented gene expression analysis.
  Patterns
• Ki-67 proliferation index is associated with tumor grade and survival in pleural epithelioid mesotheliomas.
  The American Journal of Surgical Pathology
• Creating an atlas of normal tissue for pruning WSI patching through anomaly detection.
  Scientific Reports
• Papillitis associated with IgLON5 autoimmunity: A novel clinical phenotype.
  Journal of Neuroimmunology
• Serial high sensitivity troponin sampling in patients with SARS-CoV-2 infection.
  Clinical Biochemistry
• Psychodid flies and their implicated role in human myiasis and pseudomyiasis.
  Journal of Clinical Microbiology
• Imprecision of high-sensitivity cardiac troponin assays at the female 99th-percentile.
  Clinical Biochemistry
• Induction of p16Ink4a gene expression in heme protein-induced acute kidney injury and by heme: Pathophysiologic implications.
  Kidney360
• Characteristics of blood banking/transfusion medicine fellows in the United States, 2013-2021: Lessons learned from the Transfusion Medicine In-Service Examination (TMISE) practice survey.
  Transfusion
• The lupus anticoagulant titer is associated with elevated antiphosphatidylserine/prothrombin immunoglobulin-M isotype antibody levels.
  International Journal of Laboratory Hematology
• Modeling the temporal evolution of plasma p-tau in relation to amyloid beta and tau PET.
  Alzheimers & Dementia
• Vascular risk, gait, behavioral, and plasma indicators of VCID.
  Alzheimers & Dementia

Sarah Jarvis

Sarah Jarvis is a Senior Marketing Specialist at Mayo Clinic Laboratories. She supports marketing strategies for paid media.