Mayo Clinic Laboratory and Pathology Research Roundup: March 19
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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.
Featured Abstract
Prognostic impact of SF3B1 mutation and multilineage dysplasia in myelodysplastic syndromes with ring sideroblasts: a Mayo Clinic study of 170 informative cases.
The revised 4th edition of the World Health Organization (WHO4R) classification lists myelodysplastic syndromes with ring sideroblasts (MDS-RS) as a separate entity with single lineage (MDS-RS-SLD) or multilineage (MDS-RS-MLD) dysplasia. The more recent International Consensus Classification (ICC) distinguishes between MDS with SF3B1 mutation (MDS-SF3B1) and MDS-RS without SF3B1 mutation; the latter is instead included under the category of MDS not otherwise specified. The current study includes 170 Mayo Clinic patients with WHO4R-defined MDS-RS, including MDS-RS-SLD (N=83) and MDS-RS-MLD (N=87); a subset of 145 patients were also evaluable for the presence of SF3B1 and other mutations, including 126 with (87%) and 19 (13%) without SF3B1 mutation.
Published to PubMed This Week
- Papillitis associated with IgLON5 autoimmunity: A novel clinical phenotype.
Journal of Neuroimmunology - Occult ALK-negative anaplastic large cell lymphoma complicating chronic lymphocytic leukemia.
Blood - Spinal meningeal mass lesion: A rare presentation of primary dural follicular lymphoma.
The Neurologist - Using differential mobility spectrometry to improve the specificity of targeted measurements of 2,3-dinor 11β-Prostaglandin F2α.
Clinical Biochemistry - Autoimmune central nervous system disorders: Antibody testing and its clinical utility.
Clinical Biochemistry - Functional analysis and clinical classification of 462 germline BRCA2 missense variants affecting the DNA binding domain.
American Journal of Human Genetics - Morphological findings in different subtypes of hepatic amyloid.
Human Pathology - Neurological autoimmunity in patients with non-pulmonary neuroendocrine neoplasms: clinical manifestations and neural autoantibody profiles.
European Journal of Neurology - Understanding team dynamics and culture of safety using video reflexive ethnography during real-time emergent intubation.
Annals of the American Thoracic Society - Timing and morbidity of intracranial meningioma resection complications.
World Neurosurgery
