Mayo Clinic Laboratory and Pathology Research Roundup: April 2

By Sarah Jarvis • April 2, 2024

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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

Follicular lymphoma B cells exhibit heterogeneous transcriptional states with associated somatic alterations and tumor microenvironments.

Follicular lymphoma (FL) is an indolent non-Hodgkin lymphoma of germinal center origin, which presents with significant biologic and clinical heterogeneity. Using RNA-seq on B cells sorted from 87 FL biopsies, combined with machine-learning approaches, we identify 3 transcriptional states that divide the biological ontology of FL B cells into inflamed, proliferative, and chromatin-modifying states, with relationship to prior GC B cell phenotypes.

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Published to PubMed This Week

• Cancer therapy-related cardiac dysfunction: Expanding the horizon of cardiac troponin in clinical practice.
  JACC
• Cardiac troponin in patients with light chain and transthyretin cardiac amyloidosis: JACC: CardioOncology State-of-the-Art Review.
  JACC
• Calr type 1/like mutation in myelofibrosis is the most prominent predictor of momelotinib drug survival and longevity without transplant.
  Blood Cancer Journal
• From pandemic to endemic: Divergence of COVID-19 positive-tests and hospitalization numbers from SARS-CoV-2 RNA levels in wastewater of Rochester, Minnesota.
  Heliyon
• Clinicoradiological and neuropathological evaluation of primary progressive aphasia.
  Journal of Neurology, Neurosurgery, and Psychiatry
• 2024 update on classification, etiology, and typing of renal amyloidosis.
  American Journal of Kidney Diseases
• Algorithm training and testing for a non-Endoscopic Barrett's esophagus detection test in prospective multicenter cohorts.
  Clinical Gastroenterology and Hepatology
• Hypofractionated stereotactic radiosurgery in the management of brain metastases.
  Neurosurgery
• High-grade B-cell lymphoma with a quadruple-hit genetic profile including concurrent MYC, BCL2, BCL6, and CCND1 gene rearrangements.
  Laboratory Medicine
• Determinants of confrontation naming deficits on the Boston Naming Test associated with transactive response DNA-binding protein 43 pathology.
  Journal of the International Neuropsychological Society
• IgG4-related kidney disease: Clinicopathologic features, differential diagnosis, and mimics.
  Seminars in Diagnostic Pathology
• Mimickers of immunoglobulin G4-related hepatobiliary disease on biopsy.
  Seminars in Diagnostic Pathology
• Oncolytic varicella-zoster virus engineered with ORF8 deletion and armed with drug-controllable interleukin-12.
  Journal for Immunotherapy for Cancer

Sarah Jarvis

Sarah Jarvis is a Senior Marketing Specialist at Mayo Clinic Laboratories. She supports marketing strategies for paid media.