Mayo Clinic Laboratory and Pathology Research Roundup: May 14
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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.
Featured Abstract
Trisomy 8 defines a distinct subtype of myeloproliferative neoplasms driven by the MYC-Alarmin Axis.
Despite advances in understanding the genetic abnormalities in myeloproliferative neoplasms (MPNs) and the development of JAK2 inhibitors, there is an urgent need to devise new treatment strategies, particularly for triple negative myelofibrosis (MF) patients who lack mutations in the JAK2 kinase pathway and have very poor clinical outcomes.
Published to PubMed This Week
- Ganglioglioma with anaplastic/high-grade transformation: Histopathologic, molecular, and epigenetic characterization of 3 cases.
Journal of Neuropathology and Experimental Neurology - Peripheral nerve tumors.
Handbook of Clinical Neurology - Autoimmune myelofibrosis: A Mayo Clinic series of 22 patients.
British Journal of Haematology - Neoadjuvant therapy leads to objective response in intrahepatic cholangiocarcinoma.
HPB - Hormone therapy in women with benign breast disease - What little is known and suggestions for clinical implementation.
Maturitas - Single nucleotide polymorphism (SNP) chromosomal microarray as a diagnostic tool for mucinous tubular and spindle cell carcinoma: A validation study.
Human Pathology - Morphological findings in different subtypes of hepatic amyloid.
Human Pathology - Pulmonary gangliocytic paraganglioma: An under-recognized mimic of carcinoid tumor.
Human Pathology - Sebaceous neoplasm with defective DNA mismatch repair.
Mayo Clinic Proceedings - Infliximab limits injury in myocardial infarction.
Journal of the American Heart Association - Boston Criteria v2.0 for cerebral amyloid angiopathy without hemorrhage: An MRI-Neuropathologic Validation Study.
Neurology - High lead levels in 2 independent and authenticated locks of Beethoven's hair.
Clinical Chemistry - SLC6A8 creatine transporter deficiency can be detected by plasma creatine and creatinine concentrations.
Molecular Genetics and Metabolism - Establishing hemolysis, icterus, and lipemia interference limits for body fluid chemistry analytes measured on the Roche cobas instrument.
American Journal of Pathology - A rare complex structural variant of novel intragenic inversion combined with reciprocal translocation t(X;1)(p21.2;p13.3) in Duchenne muscular dystrophy.
Neuromuscular Disorders - Trends and disparities in treatment and control of atherosclerotic cardiovascular disease in US adults, 1999 to 2018.
Journal of the American Heart Association - Should all patients with stage IE gastric mucosa-associated lymphoid tissue lymphoma receive antibiotic eradication therapy for Helicobacter pylori?
JCO Oncology Practice - Phage K exposure generates phage-neutralizing activity in a rabbit model-humoral receptiveness may impact efficacy of phage therapy.
Antimicrobial Agents and Chemotherapy - Outpatient treatment with concomitant vaccine-boosted convalescent plasma for patients with immunosuppression and COVID-19.
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