Cytology Specimen Utilization: A Proven Approach to Genetic Sequencing

May 21, 2025
11 a.m.–Noon CT

Cost

Free for all participants.

Overview

The use of cytology specimens for molecular analysis of solid tumors is a proven approach to aid in establishing a patient’s molecular diagnosis, which is a vitally important aspect of choosing the most effective treatment for a patient’s specific cancer. When the amount of available tissue specimens is inadequate for molecular testing, use of cytology specimens, including cytology smears, presents a compelling testing approach. Cytology specimen testing, however, is considerably underutilized. 

This webinar will explore the role of cytology specimens in molecular genetic testing, emphasizing their effectiveness in identifying biomarkers critical for targeted therapies in patients with cancer. Advantages of cytology samples, challenges in specimen adequacy, and how advancements in next-generation sequencing (NGS) have led to improved utilization of cytology samples will be discussed. This discovery has led to enhancing diagnostic accuracy, reducing the need for repeat biopsies, and accelerating personalized cancer treatment, all of which will be highlighted during the webinar.  

Presenters

Ying-Chun Lo Profile

Ying-Chun Lo, M.D., Ph.D.

Consultant, Anatomic Pathology
Assistant Professor of Laboratory Medicine and Pathology
Mayo Clinic
Rochester, Minnesota 

Mary Bartholet Profile

Katy Bartholet, SCT(ASCP)

Cytology Specialist 
Mayo Clinic
Rochester, Minnesota 

Learning objectives

Upon completion of this activity, participants should be able to:

  • Recognize the advantages of cytology specimens over traditional tissue biopsies. 
  • Explain best practices in specimen collection. 
  • Define how genetic sequencing has expanded the use of cytology specimens, including smears, for comprehensive genomic profiling (CGP). 

Intended audience

This webinar is appropriate for any provider who sees patients with certain cancers and solid organ tumors, including medical oncologists, pathologists, cytopathologists, nurse practitioners, physician assistants, oncology nurse navigators, interventional radiologists, and cytologists as well as laboratory directors, lab supervisors, and laboratory send-out coordinators/managers.

Credit

The following types of credit are offered for this event:

ASCLS P.A.C.E.®

Mayo Clinic Laboratories is approved as a provider of continuing education programs in the Clinical Laboratory Sciences by the ASCLS P.A.C.E.® program. This program has been approved for a maximum of 1.0 P.A.C.E.® contact hour.

State of Florida

Mayo Clinic Laboratories is approved as a Continuing Education Accrediting Agency for the Clinical Laboratory Sciences for the State of Florida. Florida Board of Clinical Laboratory Personnel has designated this program for General (Cytology) credit. This program has been approved for 1.0 contact hour.

To obtain credit


1. Register for and participate in the program.

2. Complete the evaluation that will be sent to you after the program.

3. Generate and print your certificate(s).


Level of instruction for this program is intermediate.


Faculty disclosure


Course director(s), planning committee, faculty, and all others who are in a position to control the content of this educational activity are required to disclose all relevant financial relationships with any commercial interest related to the subject matter of the educational activity. Safeguards against commercial bias have been put in place. Faculty members also will disclose any off-label and/or investigational use of pharmaceuticals or instruments discussed in their presentations. Disclosure of this information will be published in course materials so those participants in the activity may formulate their own judgments regarding the presentations.

Questions

Contact us: mcleducation@mayo.edu

MCL Education

This post was developed by our Education and Technical Publications Team.