Assay Aids Diagnosis of Resistant Hypertension


Answers From the Lab

About 20% of people taking antihypertensive medications aren't meeting their targeted blood pressure levels. In this test-specific episode of the "Answers From the Lab" podcast, John  Lieske, M.D., and Sandra Taler, M.D., explain how Mayo Clinic Laboratories' new assay can help clinicians evaluate individuals with resistant hypertension to meet blood pressure goals.

"One reason for resistant hypertension is that people aren't able to take their medications for some reason. That can be difficult to figure out clinically. But most of these drugs are eliminated by the kidneys and appear in urine," Dr. Lieske says.

Mayo Clinic Laboratories' mass spectrometry assay can detect the presence of 16 common antihypertensive drugs in patients' urine samples. Test results can spur clinical discussions of why patients aren't taking their medications, further evaluation to determine if medications aren't being properly absorbed for some reason, and potentially, new treatment plans.

"Patients with resistant hypertension have higher rates of cardiovascular complications and are more likely to have underlying or secondary causes of their hypertension," Dr. Taler says. "Studies indicate that the rate of nonadherence to antihypertensive medications is higher than we thought. There really is a role for monitoring antihypertensive drugs in body fluids."

Listen to learn more about Mayo Clinic Laboratories' hypertension assay.

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Barbara J. Toman

Barbara J. Toman is a Senior Communications Specialist at Mayo Clinic Laboratories. She is also the science writer for Mayo’s Neurosciences Update newsletter, which helps referring physicians to stay informed about Mayo’s treatment and research. Barbara has worked at Mayo Clinic since 2007. She enjoys international travel and cooking.