Real-time Quaking-induced Conversion Assays: From prion disease to emerging neurodegenerative diagnostics
Tuesday, March 10, 2026
11 a.m.–Noon CT
Cost
Free for all participants.
Overview
This webinar introduces real-time quaking-induced conversion (RT-QuIC) assays that are now available at Mayo Clinic for diagnosing human prion disease. RT-QuIC offers rapid, highly accurate detection of misfolded prion proteins in cerebrospinal fluid, fast turnaround time and high diagnostic confidence. The advantages of utilizing the Tau/p-Tau ratio as an adjunct biomarker will be explored.
Presenter
John Mills, Ph.D.
Assistant Professor of Laboratory Medicine and Pathology
Co-Director of the Neuroimmunology Laboratory
Vice Chair of Test Implementation
Division of Clinical Biochemistry
Mayo Clinic, Rochester, Minnesota
Learning objectives
Upon completion of this activity, participants should be able to:
- Differentiate the major etiologies of rapidly progressive dementia, including prion diseases and prion-like proteinopathies.
- Evaluate the diagnostic role and performance characteristics of real-time quaking-induced conversion (RT-QuIC) compared to traditional CSF and imaging biomarkers in suspected prion disease.
- Appraise the broader applications of RT-QuIC and related seeding assays for neurodegenerative disorders beyond prion disease.
Intended audience
This webinar is appropriate for laboratory leaders, healthcare providers, laboratory personnel, and other professionals involved in laboratory diagnostics or neurodegenerative disease research and who are interested in innovations and the future direction of lab medicine.
Credit
The following types of credit are offered for this event:
ASCLS P.A.C.E.®
Mayo Clinic Laboratories is approved as a provider of continuing education programs in the Clinical Laboratory Sciences by the ASCLS P.A.C.E.® program. This program has been approved for a maximum of 1.0 P.A.C.E.® contact hour.
State of Florida
Mayo Clinic Laboratories is approved as a Continuing Education Accrediting Agency for the Clinical Laboratory Sciences for the State of Florida. Florida Board of Clinical Laboratory Personnel has designated this program for General credit. This program has been approved for 1.0 contact hour.
To obtain credit
1. Register for and participate in the program.
2. Complete the evaluation that will be sent to you after the program.
3. Generate and print your certificate(s).
Level of instruction for this program is intermediate.
Faculty disclosure
Course director(s), planning committee, faculty, and all others who are in a position to control the content of this educational activity are required to disclose all relevant financial relationships with any commercial interest related to the subject matter of the educational activity. Safeguards against commercial bias have been put in place. Faculty members also will disclose any off-label and/or investigational use of pharmaceuticals or instruments discussed in their presentations. Disclosure of this information will be published in course materials so those participants in the activity may formulate their own judgments regarding the presentations.
Questions
Contact us: mcleducation@mayo.edu
