Mayo Clinic Laboratory and pathology research roundup: May 9

By Samantha Rossi • May 9, 2023

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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

Proprotein Convertase Subtilisin/Kexin Type 6 (PCSK6) is a likely antigenic target in membranous nephropathy and nonsteroidal anti-inflammatory drug use.

Drugs are an important secondary cause of membranous nephropathy (MN) with the most common drugs associated with MN being nonsteroidal anti-inflammatory drugs (NSAIDs). Since the target antigen in NSAID-associated MN is not known, we performed laser microdissection of glomeruli followed by mass spectrometry (MS/MS) in 250 cases of PLA2R-negative MN to identify novel antigenic targets. This was followed by immunohistochemistry to localize the target antigen along the glomerular basement membrane and western blot analyses of eluates of frozen biopsy tissue to detect binding of IgG to the novel antigenic target. 

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Published to PubMed This Week

• ALK-negative anaplastic large cell lymphoma with JAK2 rearrangement mimicking classic Hodgkin lymphoma.
  Blood
• An atlas of the bone marrow bone proteome in patients with dysproteinemias.
  Blood Cancer Journal
• A review of voice-based pain detection in adults using artificial intelligence.
  Bioengineering
• Heart transplantation from COVID-19-positive donors: A word of caution.
  Transplant procedures
• Same-day discharge for left atrial appendage occlusion procedure: A systematic review and meta-analysis.
  Journal of Cardiovascular Electrophysiology
• A distinctive IgG-mediated pathogenesis for primary progressive multiple sclerosis?
  Brain
• Predicting amyloid PET and tau PET stages with plasma biomarkers.
  Brain
• Predictors of response to venetoclax plus hypomethylating agent therapy and survival in blastphase myeloproliferative neoplasm.
  Haematologica
• Analysis of monoclonal immunoglobulins from bone marrow plasma cells using immunopurification and LC-MS.
  Journal of mass spectrometry and advances in the clinical lab
  

Samantha Rossi

Samantha Rossi is a Digital Marketing Manager at Mayo Clinic Laboratories. She supports marketing strategies for product management and specialty testing. Samantha has worked at Mayo Clinic since 2019.