Mayo Clinic Laboratory and pathology research roundup: June 13

By Samantha Rossi • June 13, 2023

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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

Plasma biomarkers for prediction of Alzheimer's disease neuropathologic change.

While plasma biomarkers for Alzheimer's disease (AD) are increasingly being evaluated for clinical diagnosis and prognosis, few population-based autopsy studies have evaluated their utility in the context of predicting neuropathological changes. Our goal was to investigate the utility of clinically available plasma markers in predicting Braak staging, neuritic plaque score, Thal phase, and overall AD neuropathological change (ADNC).We utilized a population-based prospective study of 350 participants with autopsy and antemortem plasma biomarker testing using clinically available antibody assay (Quanterix) consisting of Aβ42/40 ratio, p-tau181, GFAP, and NfL. 

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Published to PubMed This Week

• Amyloid-like IgM deposition neuropathy with multiple mononeuropathies and generalized neuropathy.
  Neuromuscular Disorders
• Evaluation of long-term follow-up in ecchordosis physaliphora versus chordoma.
  World Neurosurgery
• Clinicoradiologic and neuropathologic evaluation of corticobasal syndrome.
  Neurology
• "Autoimmune HIT" antibodies in diagnostic samples are a potential artifact and not associated with more severe outcomes.
  Blood Advances
• COVID-19 and glomerular diseases.
  Kidney International Reports
• Dynamics and survival associations of T cell receptor clusters in patients with pleural mesothelioma treated with immunotherapy.
  Journal of Immunotherapy Cancer
• Genetic risk scores enhance the diagnostic value of plasma biomarkers of brain amyloidosis.
  Brain
• Prognostic stratification of endometrial cancers with high microsatellite instability or no specific molecular profile.
  Frontiers in Oncology
• Dynamics and survival associations of T cell receptor clusters in patients with pleural mesothelioma treated with immunotherapy.
  Journal of Immunotherapy Cancer
  

Samantha Rossi

Samantha Rossi is a Digital Marketing Manager at Mayo Clinic Laboratories. She supports marketing strategies for product management and specialty testing. Samantha has worked at Mayo Clinic since 2019.