Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP) calculator

For guidance on when to use the calculator, please see the following algorithm: Acquired Neuropathy Diagnostic Algorithm.

Data entry for CIDP suspects having varied weakness, reduced reflexes, sensory involvements

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Criteria
Findings
1
Progression over 8 weeks
2
Proximal upper and lower limb weakness
3
Absent onset autonomic involvement (orthostasis, constipation or diarrhea, impotence)
4
Absent muscle atrophy
5
Ulnar forearm motor conduction velocity ≤ 35.7 meters/second
6
Ulnar motor conduction block ≥30%, excluding compression and Martin Gruber (yes/no)

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Probability result

The following is the probability of CIDP using a statistical model1 informed by EAN/PNS 2021 criteria2. Percentages below 92% are unlikely to have CIDP. Mimic disorders are more common with lower probability scores, but mimics can still occur in patients with scores above 92% meeting EAN/PNS 2021 criteria.1,3 Laboratory testing aids exclusion of the most common mimics: IgG4-Nodopathies (CIDP-NF155/Contactin1); paraneoplastic (AIAES); anti-MAG (MAGES); POEMS (QMPSS, VEGF); Ganglioside Antibodies Evaluation, Serum (GAES); and inherited neuropathy (PEPAN) based on clinical details.3

1. Swart G, Skolka M, Shahar S, et al. A Statistical Model Facilitates Accurate Chronic Inflammatory Demyelinating Polyradiculoneuropathy Diagnosis Combined with Laboratory Testing. JPNS 2025
2. Van den Bergh P, van Doorn P, Hadden R, et al. European Academy of Neurology/Peripheral Nerve Society guideline on diagnosis and treatment of chronic inflammatory demyelinating polyradiculoneuropathy. JPNS 2021
3. Broers MC, Bunschoten C, Drenthen J, et al. Misdiagnosis and diagnostic pitfalls of chronic inflammatory demyelinating polyradiculoneuropathy. Eur J Neurol 2021;28:2065-2073
3. Lewis, R. van Doorn, P , Sommer, C Tips in navigating the diagnostic complexities of chronic inflammatory demyelinating polyradiculoneuropathy. Journal of the Neurological Sciences 2022