Mayo Clinic Laboratory and Pathology Research Roundup: May 21

By Sarah Jarvis • May 21, 2024

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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

Monoclonal immunoglobulin crystalline nephropathies.

Monoclonal immunoglobulin (MIg) crystalline nephropathies are rare lesions resulting from precipitation of MIgs in the kidney as crystalline inclusions. They can be categorized into lesions with predominant intracellular crystals (light chain [LC] proximal tubulopathy, LC crystal-storing histiocytosis, LC crystalline podocytopathy] and lesions with predominant extracellular crystals (crystalglobulin-induced nephropathy, crystalline variant of LC cast nephropathy).

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Published to PubMed This Week

• Reduced expression of CLEC4G in neurons is associated with Alzheimer's disease.
  International Journal of Molecular Sciences
• A 3-step method for preparing cryopreserved samples of apheresis products for post-thaw analysis yields a higher percentage of viable cells.
  Transfusion
• TDP-43 is associated with subiculum and cornu ammonis 1 hippocampal subfield atrophy in primary age-related tauopathy.
  Journal of Alzheimer's Disease
• Lost in the sauce: An atypical cause of optic neuropathy.
  Journal of Neuro-Ophthamology
• Proteomic identification of plasma proteins associated with future dementia development.
  Clinical Chemistry
• Tumor mutational load is prognostic for progression to therapy among high-count monoclonal B-cell lymphocytosis.
  Blood Advances
• High frequency oscillations in human memory and cognition: a neurophysiological substrate of engrams?
  Brain
• "Insights into ALD & AUD diagnosis and prognosis: Exploring AI and multi-modal data streams".
  Hepatology
• Assay precision and risk of misclassification at rule-out cut-offs for high-sensitivity cardiac troponin.
  The Canadian Journal of Cardiology
• Importance of cerebrospinal fluid (CSF) collection protocol for the accurate diagnosis of Alzheimer's disease when using CSF biomarkers.
  Alzheimer's & Dementia
• Three-dimensional telomere profiling predicts risk of progression in smoldering multiple myeloma.
  American Journal of Hematology

Sarah Jarvis

Sarah Jarvis is a Senior Marketing Specialist at Mayo Clinic Laboratories. She supports marketing strategies for paid media.