Mayo Clinic Laboratories > Reframing diagnosis for peripheral neuropathy

Reframing diagnosis for peripheral neuropathy

Identify treatable causes by focusing on the pathological process

Affecting 20 million to 30 million individuals in the U.S., peripheral neuropathy is a life-altering, debilitating nerve disorder with multiple causes, including genetic variation, autoimmune response, and cancer. While many peripheral neuropathy types are not curable, some are. Others can be effectively managed. But because peripheral neuropathy often presents with varied phenotypes, pinpointing the correct cause can be challenging.

Driven by Mayo Clinic’s primary value that the needs of the patient come first, Mayo Clinic physicians and scientists have taken the lead in re-envisioning peripheral neuropathy testing, taking the guesswork out of delivering meaningful answers for patients affected by peripheral neuropathy.

Delivering answers with impact

To provide physicians and healthcare professionals a deeper understanding of how our testing approach helps ensure the right patient receives the right test at the right time, we’ve developed an educational resource with insights from the Mayo Clinic peripheral neuropathy experts who are on the leading edge of test development.

Our e-book is essential reading for healthcare professionals on the front lines of diagnosing and caring for patients impacted by this complex condition.

Download now

Fill out the form to download our e-book, "Peripheral neuropathy: Cutting through diagnostic dissonance with an algorithmic approach."

“We’re pretty confident that these tests and the algorithms are faithful to our belief in getting the right patient to the right test — that is a very important concept and by doing that, we can get patients to the best care.”

Christopher Klein, M.D., Mayo Clinic neurologist and neuromuscular specialist

The collaborative underpinning of innovation

The integration between the clinical practice and test developers at Mayo Clinic is the engine powering innovation at Mayo Clinic Laboratories. Through close collaboration with neurologists, neuromuscular specialists, geneticists, and other clinical experts, the most important clinical questions are woven into leading-edge testing. 

This multidisciplinary, patient-first approach not only aligns with Mayo Clinic’s core values, it also centers test development on the implementation of novel approaches that elevate patient care.

Highlights


Resources
References
  1. Hoffman EM, Staff NPRobb JM, St. Sauver JL, Dyck PJ, Klein CJ. Impairments and comorbidities of polyneuropathy revealed by population-based analyses. Neurology. 2015;84(16):1644-1651. https://doi.org/10.1212/WNL.0000000000001492
  2. Parmar JM, Laing NG, Kennerson ML, et al. Genetics of inherited peripheral neuropathies and the next frontier: looking backwards to progress forwards. J Neurol Neurosurg Psychiatry. 2024;95:992-1001.
  3. Swart G, Skolka MP, Shelly S, et al. Distinguishing chronic inflammatory demyelinating polyneuropathy from mimic disorders: the role of statistical modeling. J Peripher Nerv Syst. 2025 Mar;30(1):e12682. https://doi.org/10.1111/jns.12682
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