Featured new tests in quarter three of 2025
Featured new tests
In the third quarter of 2025, Mayo Clinic Laboratories expanded its test catalog with several innovative new tests including:
- STAT3 | Phosphorylated STAT3 at Tyrosine 705 (pSTAT3-Y705), Technical Component Only
- Used to evaluate activation of the JAK-STAT3 pathway in anaplastic large cell lymphoma (ALCL).
- Helps distinguish ALCL molecular subtypes based on STAT3 phosphorylation status.
- Supports diagnosis and treatment decisions through surrogate marker identification.
Learn more Lymphoid and plasma cell neoplasms testing
- NF2 | Merlin (NF2) Immunostain, Technical Component Only
- Identifies Merlin (NF2 gene product) expression in the membrane or cytoplasm of tumor cells.
- Helps differentiate reactive mesothelial proliferation from mesothelioma.
- Loss of NF2 expression supports the diagnosis of malignancy and enhances the sensitivity of mesothelioma markers.
- GUS | Guselkumab, Serum
- Assessing response to guselkumab therapy for treatment optimization.
- Evaluating the need for dose escalation or potential for dose de-escalation/discontinuation.
- Monitoring patients who require elevated guselkumab concentrations to improve clinical outcomes.
Learn more Biologics management
- ALWB | Aluminum, Blood
- Preferred test for routine aluminum screening.
- Monitoring metallic prosthetic implant wear.
- CYTH2 | T-Helper Cell Type 2 Cytokine Panel, Plasma
- Assessment of plasma cytokine levels to aid in identifying allergic conditions and parasitic infections.
- Supports clinical interpretation when used alongside other laboratory and diagnostic information.
- Helps clarify disease etiology through immune response profiling.
- HBRM | SWI/SNF Chromatin Remodeling Complex Subunit ATPase 2 (SMARCA2 or BRM) Immunostain, Technical Component Only
- Aids in identifying loss of SWI/SNF complex subunits in malignant rhabdoid tumors, epithelioid sarcomas, and SMARCA4-deficient tumors.
- Supports further subtyping of poorly differentiated malignancies.
- Provides diagnostic insight into tumors with disrupted chromatin remodeling pathways.
- CTPCO | ThinPrep with Human Papillomavirus (HPV) Co-Test-Screen with p16/Ki67 Dual Stain Reflex, Varies
- Screens for cervical carcinoma or intraepithelial lesions and HR-HPV in women aged 30–65.
- Aids in triaging women with abnormal Pap smear results or discordant HR-HPV/Pap findings.
- Supports colposcopy referral decisions in women with NILM and HR-HPV positivity using the cobas 4800 HPV Test.
Visit our test catalog for more information on new or updated tests and testing algorithms.
