High-Resolution Targeted MS Stimulant & Phencyclidine (PCP) Screen

This program reviews urine drug testing for stimulants and phencyclidine (PCP), with an emphasis on the advantages and limitations of traditional immunoassays and targeted mass spectrometry-based screening. A clinical case demonstrates how cross-reactivity and assay limitations can contribute to unexpected results and highlights the importance of considering the testing method, medication history, and clinical context when interpreting findings.

Learning objectives

  • Describe the clinical utility of prescription stimulant drugs.
  • Identify the advantages and limitations of urine drug tests used to support adherence monitoring or detection of abuse for controlled substances. 
  • Compare the effectiveness of immunoassays and mass spectrometry-based targeted screening assays to identify PCP drug use.
  • Differentiate how Mayo Clinic's targeted stimulant and PCP test, as well as the controlled substance monitoring panel, helps clinicians correctly interpret test results.

Intended audience

This program is intended for laboratory professionals, including medical laboratory scientists, medical laboratory technicians, clinical chemistry and toxicology professionals, laboratory supervisors and managers, and other healthcare professionals involved in ordering, performing, reviewing, or interpreting urine drug testing and controlled substance monitoring.

Questions?

Contact us: mcleducation@mayo.edu

MCL Education

This post was developed by our Education and Technical Publications Team.