Mayo Clinic Laboratory and Pathology Research Roundup: June 3

By Alyssa Frank • June 3, 2019

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The Research Roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

Joint Association of Mammographic Density Adjusted for Age and Body Mass Index and Polygenic Risk Score with Breast Cancer Risk

Mammographic breast density, adjusted for age and body mass index, and a polygenic risk score (PRS), comprised of common genetic variation, are both strong risk factors for breast cancer and increase discrimination of risk models. Understanding their joint contribution will be important to more accurately predicting risk.

Published to PubMed This Week

• Ultrastaging of Negative Pelvic Lymph Nodes to Decrease the True Prevalence of Isolated Paraaortic Dissemination in Endometrial Cancer
  Gynocologic Oncology
• Metaplastic Breast Cancer Has a Poor Response to Neoadjuvant Systemic Therapy
  Breast Cancer Research and Treatment
• Yersinia kristensenii Subsp. rochesterensis Subsp. Nov., Isolated from Human Feces
  International Journal of Systematic and Evolutionary Microbiology
• Does Argininosuccinate Synthase 1 (ASS1) Immunohistochemistry Predict an Increased Risk of Hemorrhage for Hepatocellular Adenomas?
  Applied Immunohistochemistry & Molecular Morphology
• Micropapillary Adenocarcinoma of Lung: Morphological Criteria and Diagnostic Reproducibility Among Pulmonary Pathologists
  Annals of Diagnostic Pathology
• Magnetic Resonance Elastography of Liver in Light Chain Amyloidosis
  Journal of Clinical Medicine
• Potential Influence of IDH1 Mutation and MGMT Gene Promoter Methylation on Glioma-Related Preoperative Seizures and Postoperative Seizure Control
  Seizure
• Impact of Metformin use on the Outcomes of Newly Diagnosed Diffuse Large B-Cell Lymphoma and Follicular Lymphoma
  British Journal of Haematology
• Phase I-II Trial of Imatinib Mesylate (Gleevec; STI571) in Treatment of Recurrent Oligodendroglioma and Mixed Oligoastrocytoma
  Journal of Neuro-Oncology

Alyssa Frank

Alyssa Frank is a Marketing Segment Manager at Mayo Clinic Laboratories. She leads marketing strategies for product management and specialty testing. Alyssa has worked at Mayo Clinic since 2015.