Mayo Clinic Laboratory and Pathology Research Roundup: August 10

By Samantha Rossi • August 10, 2020

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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

Rate and Predictors of Finding Monoclonal Gammopathy of Renal Significance (MGRS) Lesions on Kidney Biopsy in Patients with Monoclonal Gammopathy.

Between 2013 and 2018, we identified 6300 patients who had MG, 160 (2.5%) of whom had undergone a kidney biopsy. Of the 160 patients, 64 (40%) had an MGRS lesion; amyloid light chain amyloidosis, the most common finding, accounted for nearly half of these lesions. In the non-MGRS group comprising 96 patients, 23 had arteriosclerosis, the most common finding. In multivariate analysis, strong predictors of finding an MGRS lesion included the presence of an elevated free light chain ratio, proteinuria, and hematuria. Among 596 patients with CKD and MG from 2017 to 2018, 62 (10.4%) underwent a kidney biopsy. Kidney biopsy was deferred for 70 patients (20%); for 62 of the 70, the diagnosis was already known, and eight were not candidates for therapy. Younger age and higher proteinuria and serum creatinine levels increased the likelihood that the patient would undergo a kidney biopsy. Via Journal of American Society of Nephrology.

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Published to PubMed This Week

• Expanded Clinical Phenotype, Oncological Associations, and Immunopathologic Insights of Paraneoplastic Kelch-like Protein-11 Encephalitis.
  JAMA Neurology
• Standardized Reporting of Monoclonal Immunoglobulin-Associated Renal Diseases: Recommendations from a Mayo Clinic/Renal Pathology Society Working Group.
  Kidney International
• RNA Helicase p68 Inhibits the Transcription and Post-Transcription of Pkd1 in ADPKD.
  Theranostics
• The System Is Broken: A Qualitative Assessment of Opioid Prescribing Practices After Spine Surgery.
  Mayo Clinic Proceedings
• Cefiderocol Antimicrobial Susceptibility Testing Considerations: The Achilles Heel of the Trojan Horse?
  Journal of Clinical Microbiology
• Imipenem-Relebactam Susceptibility Testing of Gram-Negative Bacilli by Agar Dilution, Disk Diffusion, and Gradient Strip Methods Compared with Broth Microdilution.
  Journal of Clinical Microbiology
• Performance Characteristics of Four High-Throughput Immunoassays for Detection of IgG Antibodies against SARS-CoV-2.
  Journal of Clinical Microbiology
• Clinical Characteristics and Treatment Outcomes of Newly Diagnosed Multiple Myeloma with Chromosome 1q Abnormalities.
  Blood Advances
• Association of α 1 Antitrypsin Phenotype and Development of Advanced Liver Disease and Pulmonary Complications Before and After Liver Transplantation.
  Transplantation
• Automation and Validation of a MALDI-TOF MS (Mass-Fix) Replacement of Immunofixation Electrophoresis in the Clinical Lab.
  Clinical Chemistry Laboratory Medicine

Samantha Rossi

Samantha Rossi is a Digital Marketing Manager at Mayo Clinic Laboratories. She supports marketing strategies for product management and specialty testing. Samantha has worked at Mayo Clinic since 2019.