Mayo Clinic Laboratory and pathology research roundup: November 30

By Chantell Canfield • November 30, 2021

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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

Tumor junction burden and antigen presentation as predictors of survival in mesothelioma treated with immune checkpoint inhibitors.

The favorable outcomes with immunotherapy for mesothelioma were somewhat unexpected since this tumor has a low tumor mutation burden which has been associated with benefit in other cancers. Since chromosomal rearrangements are common in mesothelioma and have neoantigenic potential, we sought to determine whether they are associated with survival in patients treated with immunotherapy.

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Published to PubMed This Week

• Aetiology and incidence of sudden cardiac arrest and death in young competitive athletes in the USA: a 4-year prospective study.
  British Journal of Sports Medicine
• Human cancers express TRAILshort, a dominant negative TRAIL Splice Variant, which impairs immune effector cell killing of tumor cells.
  Clinical Cancer Research
• MYC break-apart FISH probe set reveals frequent unbalanced patterns of uncertain significance when evaluating aggressive B-cell lymphoma.
  Blood Cancer Journal
• Corrigendum to Heybeli C, Bentall A, Wen J, et al. A study from the Mayo Clinic evaluated long-term outcomes of kidney transplantation in patients with immunoglobulin light chain amyloidosis. Kidney Int. 2021;99:707-715.
  Kidney International
• The characteristics of patients with kidney light chain deposition disease concurrent with light chain amyloidosis.
  Kidney International
• A novel wireless ECG system for prolonged monitoring of multiple zebrafish for heart disease and drug screening studies.
  Biosens and Bioelectronics
• LGI1 antibody encephalitis: acute treatment comparisons and outcome.
  Journal of Neurology, Neurosurgery and Psychiatry
• Deciphering the individual contribution of absolute neutrophil and monocyte counts to thrombosis risk in polycythemia vera and essential thrombocythemia.
  American Journal of Hematology
• Measles, Rubella & Mumps titers post chemotherapy plus Autologous stem cell transplant in multiple Myeloma patients.
  American Journal of Hematology
• Glial Fibrillary acidic protein immunoglobulin G in CSF: A biomarker of severe but reversible Encephalitis.
  Neurology

Chantell Canfield

Chantell Canfield is a web content coordinator for Mayo Clinic Laboratories. She began working for Mayo Clinic in 2021.