Mayo Clinic Laboratory and pathology research roundup: March 1
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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.
Featured Abstract
Phase II randomized trial of transoral surgery and low-dose intensity modulated radiation therapy in resectable p16+ locally advanced oropharynx cancer: An ECOG-ACRIN cancer research group trial (E3311).
Definitive or postoperative chemoradiation (CRT) is curative for human papillomavirus-associated (HPV+) oropharynx cancer (OPC) but induces significant toxicity. As a deintensification strategy, we studied primary transoral surgery (TOS) and reduced postoperative radiation therapy (RT) in intermediate-risk HPV+ OPC.
Published to PubMed This Week
- Addition of navitoclax to ongoing ruxolitinib therapy for patients with Myelofibrosis with progression or suboptimal response: Phase II safety and efficacy.
Journal of Clinical Oncology - Breast cancer screening strategies for women with ATM, CHEK2, and PALB2 pathogenic variants: A comparative modeling analysis.
JAMA Oncology - Enhancer retargeting of CDX2 and UBTF::ATXN7L3 define a subtype of high-risk B-progenitor acute lymphoblastic leukemia.
Blood - Treatment of pouchitis, Crohn's disease, cuffitis, and other inflammatory disorders of the pouch: consensus guidelines from the international Ileal pouch consortium.
The Lancet: Gastroenerology and Hepatology - The 2021 WHO classification of tumors of the thymus and mediastinum: What is new in thymic epithelial, germ cell, and mesenchymal tumors?
Journal of Thorac Oncology - A clinically compatible drug-screening platform based on organotypic cultures identifies vulnerabilities to prevent and treat brain metastasis.
EMBO Molecular Medicine - High-dimensional and single-cell transcriptome analysis of the tumor microenvironment in angioimmunoblastic T cell lymphoma (AITL).
Leukemia - Polygenic risk score and risk of monoclonal B-cell lymphocytosis in caucasians and risk of chronic lymphocytic leukemia (CLL) in African Americans.
Leukemia - A simple additive staging system for newly diagnosed multiple myeloma.
Blood Cancer Journal - European LeukemiaNet-defined primary refractory acute myeloid leukemia: the value of allogeneic hematopoietic stem cell transplant and overall response.
Blood Cancer Journal
