Mayo Clinic Laboratory and pathology research roundup: June 28

By Samantha Rossi • June 28, 2022

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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

Understanding "Patient refuses" among 90+ year old patients with cancer or presumed cancer.

Patients who are 90+ years of age are a growing - but understudied - group at risk for cancer. Because many of these patients are undertreated (with no tissue/cytologic diagnosis), we sought to better understand how such decisions are arrived upon. This study focused on patients between 2007 and 2017. None had received cancer therapy. Medical records were reviewed for quotations relevant to decision-making and analyzed qualitatively. Ninety-four patients (median age 93 years) with a cancer diagnosis/presumed diagnosis were identified; most were women (82%) with an average of six co-morbidities (dementia occurred in approximately one-third).

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Published to PubMed This Week

• A blinded randomized trial comparing standard activated clotting time heparin management to high target active clotting time and undividualized hepcon HMS heparin management in cardiopulmonary bypass cardiac surgical patients.
  Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia
• Association between plasma biomarkers of amyloid, tau, and neurodegeneration with cerebral microbleeds.
  Journal of Alzheimer's disease : JAD
• Simulation as soothsayer: simulated surgical skills MMIs during residency interviews are associated with first year residency performance.
  Journal of surgical education
• Enterochromaffin cells-gut microbiota crosstalk: underpinning the symptoms, pathogenesis, and pharmacotherapy in disorders of gut-brain interaction.
  Journal of neurogastroenterology and motility
• Anti-Phosphatidylserine prothrombin antibodies as a predictor of the lupus anticoagulant in an all-comer population.
  Journal of thrombosis and haemostasis : JTH
• Immunity to SARS-CoV-2: what do we know and should we be testing for it?
  Journal of clinical microbiology
• Antimicrobial susceptibility of Elizabethkingia species: report from a reference laboratory.
  Journal of clinical microbiology
• The false promise of cellular tests for Lyme borreliosis.
  The Lancet. Infectious diseases
• Omics and AI advance biomarker discovery for liver disease.
  Nature medicine
• Surveillance mammography after treatment for male breast cancer.
  Breast cancer research and treatment
• A reverse-transcription droplet digital PCR assay to detect and quantify SARS-CoV-2 RNA in upper respiratory tract specimens.
  Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
• Success of the autologous stem cell boost after autologous graft failure in multiple myeloma and AL amyloidosis.
  Bone marrow transplantation
• Major adverse cardiovascular events after diagnosis of myocardial injury and types 1 and 2 myocardial infarction.
  European heart journal. Acute cardiovascular care
• Development of a deep learning model for the histological diagnosis of dysplasia in Barrett's esophagus.
  Gastrointestinal endoscopy
• Utilization of skin biopsy for diagnosis in a case of Lafora disease.
  Journal of cutaneous pathology
• Metagenomic shotgun sequencing of blood to identify bacteria and viruses in leukemic febrile neutropenia.
  PloS one

Samantha Rossi

Samantha Rossi is a Digital Marketing Manager at Mayo Clinic Laboratories. She supports marketing strategies for product management and specialty testing. Samantha has worked at Mayo Clinic since 2019.