Mayo Clinic Laboratory and pathology research roundup: August 30

By Samantha Rossi • August 30, 2022

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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

Kidney biopsy chronicity grading in antineutrophil cytoplasmic antibody-associated vasculitis

Kidney biopsy is valuable for prognostic assessment of renal outcomes in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) with glomerulonephritis (AAV-GN) but the impact of chronic changes is not determined. We conducted a retrospective cohort study of myeloperoxidase (MPO)- or proteinase 3 (PR3)-ANCA-positive patients with AAV and active renal disease. We applied the Mayo Clinic Chronicity Score (MCCS) and validated and evaluated its implications on outcome prediction in AAV-GN. Chronic changes on kidney histology independently predict renal function, outcomes and response to treatment in AAV-GN.

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Published to PubMed This Week

• Evaluating the significance of pancreatobiliary fish polysomy on prognosis in de novo cholangiocarcinoma
  Clinical and translational gastroenterology
• Off-the-shelf cryopreserved platelets for the detection of HIT and VITT antibodies
  Blood
• Dysexecutive Alzheimer's disease with Lewy body disease co-pathology
  Current Alzheimer research
• Flurofamide prevention and treatment of ureaplasma-induced hyperammonemia
  Microbiology spectrum
• How do frontline healthcare workers learn from COVID-19 webinars during a pandemic? An online survey study
  Hospital practice (1995)
• Acinetobacter baumannii genomic sequence-based core genome multilocus sequence typing using Ridom SeqSphere+ and antimicrobial susceptibility prediction in ARESdb
  Journal of clinical microbiology
• Monkeypox 2022: gearing up for another potential public health crisis
  Mayo Clinic proceedings
• Outcomes of allogeneic transplant in patients with DDX41 mutated myelodysplastic syndrome and acute myeloid leukemia
  Bone marrow transplantation
• Operative management of cardiac papillary fibroelastomas
  The Journal of thoracic and cardiovascular surgery
• Video feedback with error-focused or correct-focused examples in surgical skills distance learning: a randomized trial
  Surgery
  

Samantha Rossi

Samantha Rossi is a Digital Marketing Manager at Mayo Clinic Laboratories. She supports marketing strategies for product management and specialty testing. Samantha has worked at Mayo Clinic since 2019.