Mayo Clinic Laboratory and pathology research roundup: March 7

By Chantell Canfield • March 7, 2023

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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

Membranous nephropathy in syphilis is associated with neuron-derived neurotrophic factor

Syphilis is a common worldwide sexually transmitted infection. Proteinuria may occur in patients with syphilis. Membranous nephropathy (MN) is the most common cause of proteinuria in syphilis. The target antigen of MN in syphilis is unknown. This study shows that MN in syphilis is associated with a novel target antigen called neuron-derived neurotrophic factor (NDNF). NDNF-associated MN has distinctive clinical and pathologic manifestations and NDNF appears to be the target antigen in syphilis-associated MN.

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Published to PubMed This Week

• Apolipoprotein H induces sex-specific steatohepatitis and gut dysbiosis during chronic hepatitis B infection
  iScience
• Genomic markers of recurrence risk in atypical meningioma following gross total resection
  Neuro-Oncology Advances
• Genotypic and predicted phenotypic analysis of SARS-COV-2 Omicron subvariants in immunocompromised patients with COVID-19 following tixagevimab-cilgavimab prophylaxis
  Journal of Clinical Virology
• Profiling the Immune Response to Periprosthetic Joint Infection and Non-Infectious Arthroplasty Failure
  Antibiotics (Basel)
• The Brief Case: the Cryptic Cryptococcus
  Journal of Clinical Microbiology
• Association of raloxifene and tamoxifen therapy with cognitive performance, odds of mild cognitive impairment, and brain MRI markers of neurodegeneration
  Cancer Medicine
• Perceived age as a mortality and comorbidity predictor: A systematic review
  Aesthetic Plastic Surgery
• Anticoagulation after bioprosthetic aortic valve replacement: Are we following the guidelines?
  The Annals of Thoracic Surgery
• mTORC2 contributes to systemic autoimmunity
  Immunology
  

Chantell Canfield

Chantell Canfield is a web content coordinator for Mayo Clinic Laboratories. She began working for Mayo Clinic in 2021.