Oncology

This week’s Research Roundup highlights the risk of MGUS in relatives of multiple myeloma cases by clinical and tumor characteristics.

This week’s Research Roundup highlights hepatocellular carcinoma detection by plasma methylated DNA through a discovery, phase I pilot, and phase II clinical validation.

This week’s Research Roundup highlights biphenotypic acute leukemia versus myeloid antigen-positive ALL: Clinical relevance of WHO criteria for mixed phenotype acute leukemia.

Clinical studies at the Mayo Clinic have shown that this broad, but tumor-specific, genetic analysis has significant, and sometimes unexpected, clinical impact. The following case studies highlight the importance and clinical utility of these assays in diagnosis, prognosis, and therapy selection.

A research team led by Fergus Couch, Ph.D., a geneticist at Mayo Clinic, has identified specific genes associated with an increased risk for developing triple-negative breast cancer. The team's research was published in the Journal of the National Cancer Institute.

Minetta Liu, M.D., an oncologist at Mayo Clinic, answered a reader's question in Mayo Clinic's "Q and A" about liquid biopsies. The question was, "What is a liquid biopsy? Can it be used in place of a tumor biopsy to find cancer?"

This week’s Research Roundup highlights the association between inherited germline mutations in cancer predisposition genes and risk of pancreatic cancer.

This week’s Research Roundup highlights the comparison of risk stratification models to predict recurrence and survival in pleuropulmonary solitary fibrous tumor.

This week’s Research Roundup highlights the association between inherited germline mutations in cancer predisposition genes and risk of pancreatic cancer.

According to Mayo Clinic research published in JAMA, six genes contain mutations that may be passed down in families, substantially increasing a person’s risk for pancreatic cancer.

This week’s Research Roundup highlights the detection of gastric cancer with novel methylated DNA markers: discovery, tissue validation, and pilot testing in plasma.

This week’s Research Roundup highlights the development and validation of a prostate cancer genomic signature that predicts early androgen deprivation therapy (ADT) treatment response following radical prostatectomy.

Melanoma, the skin cancer often associated with sun exposure, is on the rise and has no reliable cure. Mayo Clinic is at the forefront of these efforts. The Center for Individualized Medicine is unraveling the complex behavior of melanoma at the molecular level—to allow for treatment that better targets an individual's disease.