Celiac disease

Working in collaboration with our clinical GI colleagues, we have established several cascading algorithms to aid in diagnosis. These algorithms, available as orderable clinical tests, use automatic reflexing to perform the necessary tests. Knowledge about the patient’s clinical presentation, past treatment, and previous laboratory testing is critical to selecting the most appropriate algorithm.

Key testing

• CDSP | Celiac Disease Serology Cascade, Serum
  • Helpful when HLA DQ typing is not desired or has been previously performed.
  • Interpretive report includes recommendations on the need for confirmatory biopsy.
• CDCOM | Celiac Disease Comprehensive Cascade, Serum and Whole Blood
  • Includes both serologic and genetic testing (HLA DQ typing).
  • Can completely rule out celiac disease in about 50% of patients based on HLA typing.
  • Includes individual test results, clinical interpretation, and recommendations on whether to proceed to biopsy or pursue another diagnosis.
• CDGF | Celiac Disease Gluten-Free Cascade, Serum and Whole Blood
  • Developed to assist in evaluating patients who have already reduced gluten in their diets.
  • Includes HLA DQ typing as the initial test.
• CELI | Celiac Associated HLA-DQ Alpha 1 and DQ Beta 1 DNA Typing, Blood
  • Assists in guiding therapy decisions by determining immunogenicity to anti-TNF therapy through genetic typing of the HLA-marker DQA1*05 allele.