Lymphoid/myeloid neoplasms with eosinophilia are a group of rare, significantly diverse hematologic malignancies characterized by rearrangements of the PDGFRA, PDGFRB, FGFR1, JAK2, or ABL1 genes that result in the formation of fusion transcripts and abnormal tyrosine kinase activity. Despite varying clinical presentations, the diagnostic subgroup shares rearrangements involving four specific gene regions.1
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Patients with the condition can present with myeloproliferative neoplasm, myelodysplastic syndrome, and de novo or secondary mixed phenotype leukemias. While eosinophilia often accompanies the illness, it is not always present.2
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