T-cell lymphoma
Expert-developed testing to aid in diagnosis, prognosis, and disease monitoring
With more than 30 identified subtypes of T-cell neoplasms, diagnosis can be difficult. We offer a full portfolio of testing for T-cell lymphoma, including molecular panels, comprehensive fluorescence in situ hybridization (FISH) panels, and extensive immunohistochemistry (IHC) offerings to diagnose and monitor T-cell lymphoma.
In addition, our hematopathology team has extensive experience with T-cell neoplasms, providing guidance and answers for clients and patients worldwide.
T-cell lymphoma Test menu
T-cell lymphoma FISH Testing
Key testing
- TLPDF | T-Cell Lymphoma, Diagnostic FISH, Varies
- When ordered, entire TLP FISH panel will be performed.
- TLPMF | T-Cell Lymphoma, Specified FISH, Varies
- Probe set(s) to be performed must be specified upon ordering. Any probe set captured under TLPDF can be ordered.
- TLYM | T-Cell Lymphoma, FISH, Tissue
- Performed on paraffin-embedded tissue. Probe set(s) to be performed based on pathology evaluation, reason for referral, or what is specified upon ordering.
- PATHC | Pathology Consultation
- Useful for obtaining second opinion on specimens referred by the primary pathologist.
Highlights
Andrew Feldman, M.D., discusses the different tools and techniques Mayo Clinic Laboratories uses to accurately diagnose and classify T-cell lymphomas to help provide clinicians with the diagnostic answers they need to treat their patients.
T-cell lymphoma next-generation sequencing
When deemed clinically necessary, next-generation sequencing (NGS) can supplement standard-of-care morphology, phenotyping, and FISH testing to refine diagnosis. Our unique MayoComplete T-cell lymphoma panel evaluates 26 genes with known diagnostic, prognostic, or therapeutic value in various T-cell lymphoma subtypes.
While the molecular subclassification of T-cell lymphoma continues to evolve, there are specific patterns of mutation that can be observed in select subtypes, such as angioimmunoblastic T-cell lymphoma (AITL) and large granular lymphocytic leukemia (T-LGL). Recognition of these mutational profiles using the genes provided in our panel can inform on the differential diagnosis of rare or not otherwise specified T-cell lymphomas and guide the selection of a targeted treatment.
Key testing
- NGTCL | MayoComplete T-Cell Lymphoma, Next-Generation Sequencing, Varies
- Evaluates 26 genes and select intronic regains to aid in establishing the differential diagnosis of various T-cell lymphoma subtypes and resolving complex or atypical presentations.
- Identifies key mutational profiles in AITL (TET2, DNMT3A, RHOA), T-LGL (STAT3, STAT5B),
- and other various T-cell lymphomas.
- Can facilitate diagnosis of TFH lymphoma and support diagnosis of T-cell or NK-cell LGL.
- Supports physicians in the identification of actionable mutations with a potentially therapeutic target.