
Mayo Clinic Classical Hematology Conference: Nonmalignant Hematology and Bleeding and Thrombotic Disorders
Overview
This conference will provide reviews and updates about the laboratory and clinical aspects of nonmalignant hematology and bleeding and thrombotic disorders. Combining the clinical and laboratory experience of Mayo Clinic faculty, we will illustrate available diagnostic tools to help guide the diagnosis and the treatment of rare disorders of classical hematology. Informational presentations will be supplemented with case presentations, followed by time for participant questions.
Accessibility statement: The Mayo Clinic College of Medicine and Science (MCCMS) strives for inclusive learning and training environments. If you experience or anticipate experiencing any disability related barriers, please contact Disability Access Services at MCCMS.DS@mayo.edu
Conference Information
Date: Oct. 23–25, 2025
Location: Hotel Valley Ho, 6850 East Main St, Scottsdale, AZ 85251 and via livestream
Presented by: Mayo Clinic Laboratories
Questions: Contact the Education Department at 800-533-1710 or 507-284-3156, or email mcleducation@mayo.edu.
Learning objectives
Upon completion of the conference, participants should be able to:
- Summarize clinical updates in management of patients with bleeding disorders.
- Recognize laboratory tools available for diagnosis and management of bleeding disorders.
- Describe evaluation and treatment of thrombotic disorders.
- Describe the algorithmic strategy for the diagnostic work-up of various red blood cell and platelet disorders.
- Interpret the recent advances in the management of various red blood cell and platelet disorders.
- Describe how to diagnose and manage various vascular disorders.
Intended audience
This conference is designed for specialty providers such as residents/fellows, lab techs, nurses, hematologists, oncologists, hematopathologists, and pathologists. Providers in primary care specialties, such as family medicine and internal medicine, with an interest in hematology, would also benefit from attending this conference. It is also well-suited for advanced practice providers such as nurse practitioners and physician assistants.
Agenda
Thursday, October 23, 2025
THEME 1: | TOPIC Hemophilia Advances |
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8:00 AM | TOPIC: Hemophilia Therapy Updates SPEAKER: Ewa Wysokinska, M.D. 1. Discuss advances in factor replacement therapy 2. Discuss rebalancing therapy |
8:25 AM | TOPIC: Gene Therapy Update SPEAKER: Rajiv Pruthi, M.B.B.S. 1. Discuss gene therapy for hemophilia A 2. Discuss gene therapy for hemophilia B |
8:50 AM | TOPIC: Factor Inhibitor Management SPEAKER: Meera Sridharan, M.D., Ph.D. 1. Discuss management of inhibitors in patients with congenital hemophilia 2. Discuss diagnosis and management of acquired hemophilia A |
9:15 AM | TOPIC: Laboratory Monitoring for Hemophilia in the Era of New Therapeutics SPEAKER: Rajiv Pruthi, M.B.B.S. 1. Highlight optimal assays for monitoring factor replacement therapy 2. Discuss consideration of lab monitoring for patients on emicizumab, rebalancing therapies and gene therapy |
9:40 AM | TOPIC: Q & A Panel SPEAKER: Ewa Wysokinska, M.D.; Rajiv Pruthi, M.B.B.S.; Meera Sridharan, M.D., Ph.D. |
10:00 AM | Break |
THEME 2: | TOPIC Hemostasis Potpourri |
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10:30 AM | TOPIC: Understanding Newer Assays and Genetic Testing SPEAKER: Jansen Seheult, M.B., B.Ch., B.A.O., M.D. 1. Discuss updates on assays for VWD 2. Discuss role of genetic testing for VWD and Inherited platelet disorders |
10:55 AM | TOPIC: von Willebrand Disease: practice update SPEAKER: Leslie Padrnos, M.D. 1. Discuss diagnosis of Von Willebrand disease 2. Discuss the management of Von Willebrand disease |
11:20 AM | TOPIC: Heavy menstrual bleeding: How hematologists can help SPEAKER: Julianna Perez Botero, M.D. 1. Discuss tools to help quantify menorrhagia 2. Discuss hemostatic laboratory testing 3. Highlight non-surgical treatment approaches |
11:45 AM | TOPIC: Hemostasis in Trauma SPEAKER: Pierre Noel, M.D. 1. Discuss an approach to managing hemostasis in the setting of trauma 2. Review management of massive transfusion protocol |
12:10 PM | TOPIC: Q & A Panel SPEAKER: Jansen Seheult, M.B., B.Ch., B.A.O., M.D.; Leslie Padrnos, M.D.; Julianna Perez Botero, M.D.; Pierre Noel, M.D. |
12:30 PM | Lunch |
THEME 3: | TOPIC Platelets |
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1:30 PM (40 Mins) | TOPIC: Updates in Immune Thrombocytopenia SPEAKER: Adam Cuker, M.D. 1. Identify new treatment regimens for ITP 2. Discuss strategies to manage refractory ITP |
2:10 PM | TOPIC: Qualitative Platelet Testing: What and When to Order SPEAKER: Dong Chen, M.D., Ph.D. 1. Discuss tools for evaluation of qualitative platelet disorders 2. Identify appropriate clinical situations to obtain qualitative platelet testing |
2:35 PM | TOPIC: Qualitative Platelet Disorders SPEAKER: Zoey Harris, M.D. 1. Discuss clinical presentation of qualitative platelet disorders, acquired and congenital 2. Review management strategies |
3:00 PM | TOPIC: Thrombotic Microangiopathy Updates SPEAKER: Meera Sridharan, M.D., Ph.D. 1. Discuss updates in treatment of TTP 2. Discuss updates in treatment of CM-TMA |
3:25 PM | TOPIC: Q & A Panel SPEAKER: Adam Cuker, M.D.; Dong Chen, M.D., Ph.D.; Zoey Harris, M.D.; Meera Sridharan, M.D., Ph.D. |
3:45 PM | Product Theatre |
Friday, October 24, 2025
THEME 4: | TOPIC Vascular |
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8:00 AM | TOPIC: Developing Best Imaging Practices SPEAKER: Mark Sugi, M.D. 1. Pros and Cons of different imaging practices in venous thromboembolism detection 2. Review best practices for detecting May Thurner anatomy |
8:25 AM | TOPIC: Hereditary Hemorrhagic Telangiectasia SPEAKER: Vivek Iyer, M.D., M.P.H. 1. Discuss diagnosis of HHT 2. Discuss management of HHT |
8:50 AM | TOPIC: Understanding the Bleeding Risk from Ehlers-Danlos Syndrome SPEAKER: Stephen Thome, M.D. 1. Describe the pathophysiology and clinical presentations of Ehlers-Danlos Syndrome 2. Review hemostatic management strategies for Ehlers-Danlos Syndrome patients |
9:15 AM | TOPIC: Antithrombotic Management in the Post-vascular Intervention Setting SPEAKER: Fadi Shamoun, M.D. 1. Discuss the differences in antithrombotic management for arterial and venous thrombosis/stenosis 2. Review antithrombotic management for common vascular procedures |
9:40 AM | TOPIC: Q & A Panel SPEAKER: Mark Sugi, M.D.; Vivek Iyer, M.D., M.P.H.; Stephen Thome, M.D.; Fadi Shamoun, M.D. |
10:00 AM | Break |
THEME 5: | TOPIC Thrombosis |
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10:30 AM (40 Mins) | TOPIC: Dr. William Nichols Keynote Lecture: Anticoagulation in Challenging Scenarios SPEAKER: Stephan Moll, M.D. 1. Review how to manage recurrent thrombosis despite anticoagulation 2. Discuss strategies for temporarily discontinuing anticoagulation in high-bleeding risk situations |
11:10 AM | TOPIC: Thrombophilia Assays: when to order and what to do with the results SPEAKER: Damon Houghton, M.D., M.S. 1. Identify the target population to test for thrombophilia 2. Review testing in family members |
11:35 AM | TOPIC: Perioperative Management of Heparin Induced Thrombocytopenia SPEAKER: Ana Casanegra, M.D., M.S. 1. Discuss how to manage HIT in the preoperative setting 2. Discuss when and how to rechallenge patients with heparin when required during cardiopulmonary bypass |
12:00 PM | TOPIC: Q & A Panel SPEAKER: Stephan Moll, M.D.; Damon Houghton, M.D., M.S.; Ana Casanegra, M.D., M.S. |
12:30 PM | Lunch |
THEME 6: | TOPIC CBC Abnormalities |
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1:30 PM | TOPIC: Approach to Neutropenia SPEAKER: Surbhi Shah, M.B.B.S. 1. Discuss diagnostic algorithm for neutropenia 2. Discuss treatment of neutropenia with a focus on neutropenia of unknown etiology |
1:55 PM | TOPIC: Understanding Varying Ferritin Assays and Clinical implications SPEAKER: Marwan Shaikh, M.D. 1. Provide an overview of the different ferritin assays 2. Understand the clinical impact of varying ferritin assays |
2:20 PM | TOPIC: CAR T-cell Therapy for Classical Hematology SPEAKER: Madiha Iqbal, M.B.B.S., M.D. 1. Describe Car-T cell therapy process 2. Describe use of Car T cell Therapy in Classical hematology disorders |
2:45 PM | TOPIC: Approach to JAK2 negative Erythrocytosis SPEAKER: Candido Rivera, M.D. 1. Discuss diagnostic approach for JAK2 negative erythrocytosis 2. Discuss management of Jak2 negative erythrocytosis |
3:10 PM | TOPIC: Q & A Panel SPEAKER: Surbhi Shah, M.B.B.S.; Marwan Shaikh, M.D.; Madiha Iqhal, M.B.B.S., M.D.; Candido Rivera, M.D. |
3:30 PM | Product Theatre |
Saturday, October 25, 2025
THEME 7: | TOPIC Hemolytic anemia |
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8:00 AM | TOPIC: Understanding Autoimmune Hemolytic anemia SPEAKER: Ronald Go, M.D. 1. Review diagnosis of autoimmune hemolytic anemia 2. Discuss management of autoimmune hemolytic anemia |
8:25 AM | TOPIC: Approach to non-immune hemolytic anemia SPEAKER: Richard Godby, M.D. 1. Describe diagnostic approach for non-immune hemolytic anemia 2. Highlight treatment options |
8:50 AM | TOPIC: Management of Sickle Cell Disease SPEAKER: Mustaqeem Siddiqui, M.D., M.B.A. 1. Recognized common complications of sickle cell disease and typical management approaches 2. Discuss disease modifying therapies, gene therapy, and transplant |
9:15 AM | TOPIC: Hemoglobinopathy lab assessment SPEAKER: Jennifer Herrick, M.D. 1. Recognize laboratory assays available for hemoglobinopathy diagnosis |
9:40 AM | TOPIC: Q & A Panel SPEAKER: Ronald Go, M.D.; Richard Godby, M.D.; Mustaqeem Siddiqui, M.D., M.B.A.; Jennifer Herrick, M.D. |
10:00 AM | Break |
THEME 8: | TOPIC Miscellaneous |
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10:30 AM | TOPIC: Classical Hematology's Role in Oncology Consults SPEAKER: Donald Northfelt, M.D. 1. Describe a framework for evaluation of cytopenias in the setting of oncology consults 2. Review updates of anticoagulation management in the setting of malignancy |
10:55 AM | TOPIC: PNH SPEAKER: David Dingli, M.D., Ph.D. 1. Discuss clinical presentation and diagnosis of PNH 2. Discuss treatment of PNH |
11:20 AM | TOPIC: Monoclonal gammopathy of thrombotic significance SPEAKER: Anand Padmanabhan M.D., Ph.D. 1. Recognize that monoclonal anti-Platelet Factor 4 (PF4) antibodies can mediate thrombosis in a condition referred to as monoclonal gammopathy of thrombotic significance (MGTS) 2. Discuss heterogeneity in clinical presentation and serology in MGTS |
11:45 AM | TOPIC: AI in Classical Hematology SPEAKER: Jansen Seheult, M.B., B.Ch., B.A.O., M.D. 1. Describe applications of AI within the classical hematology laboratory practice 2. Describe application of AI within the classical hematology clinical practice |
12:10 PM | TOPIC: Q & A Panel SPEAKER: Donald Northfelt, M.D.; David Dingli, M.D., Ph.D.; Anand Padmanabhan M.D., Ph.D.; Jansen Seheult, M.B., B.Ch., B.A.O., M.D. |
12:30 PM | Lunch |
1:00 to 3:00 PM | Poster Presentation |
Faculty
Course directors
Guest faculty

Adam Cuker, M.D., M.S.
Section Chief, Hematology, Penn Medicine
Clinical Director, Penn Blood Disorders Center
Director, Penn Comprehensive and Hemaophilia Thrombosis Program
Renowned for his expertise in disorders of hemostasis and thrombosis.

Stephan Moll, M.D.
Professor of Medicine, Division of Hematology, UNC School of Medicine
A leading authority on vascular disorders, known for his innovative approaches and engaging presentations.
Planning committee

Christina Chin, MPAS, P.A.-C.

Rachelle Rouse, APRN, C.N.P., R.N.
Mayo Clinic faculty

Zoey Harris, M.D.

Jansen Seheult, M.B., B.Ch., B.A.O., M.D.
Credit
Accreditation statement

In support of improving patient care, Mayo Clinic College of Medicine and Science is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.
Credit statement(s):
AMA
Mayo Clinic College of Medicine and Science designates this live activity for a maximum of 16.00 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
AAPA

Mayo Clinic College of Medicine and Science has been authorized by the American Academy of PAs (AAPA) to award AAPA Category 1 CME credit for activities planned in accordance with AAPA CME Criteria. This activity is designated for 16.00 AAPA Category 1 CME credits. PAs should only claim credit commensurate with the extent of their participation.
ANCC
Mayo Clinic College of Medicine and Science designates this activity for a maximum of 16.00 ANCC contact hours. Nurses should claim only the credit commensurate with the extent of their participation in the activity.
American Board of Internal Medicine (ABIM)
Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 16.00 MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.
Royal College of Physicians and Surgeons of Canada
Through an agreement between the Accreditation Council for Continuing Medical Education and the Royal College of Physicians and Surgeons of Canada, medical practitioners participating in the Royal College MOC Program may record completion of accredited activities registered under the ACCME’s “CME in Support of MOC” program in Section 3 of the Royal College’s MOC program.
Travel & accommodations
October is one of the best times of year to visit Scottsdale. With sunny skies, mild temperatures, and a vibrant arts scene, it’s the perfect setting for this year’s event.
Our host venue, Hotel Valley Ho, is a mid-century modern gem located in the heart of the Old Town Arts District. Surrounded by eclectic galleries, boutique shops, and some of Arizona’s top restaurants, the area comes alive during the long-running Thursday Night Art Walk.

A block of rooms has been secured at Hotel Valley Ho for participants and their guests, with special conference rates. To receive the special rate, you must make reservations before the room block is filled or before the expiration date of Oct. 1, 2025, whichever comes first. Reservations submitted following this date will be subject to availability.
- Single rate: $339
- Double rate: $339
Click here to make your reservation online. You may also call the on-site reservations department at 844-993-9601. Identify yourself as a participant of the Mayo Clinic 2025 Classical Hematology Conference when making a reservation.
Registration
Classical Hematology 2025 will be held Oct. 23-25 in Scottsdale, Arizona. The conference will be offered in person and via livestream.
- Full fee (M.D./Ph.D.): $875
- Reduced fee (resident, fellow, advanced practice provider, nurse, other): $775
Cancellation policy
If you cancel your participation in this conference on or before Oct. 2, 2025, your registration fee, less a $75 administrative fee, will be refunded. Mayo Clinic Laboratories’ Education Department must receive written notification of your cancellation. No refunds will be made after Oct. 2, 2025.
Mayo Clinic Laboratories reserves the right to cancel or postpone any conference due to unforeseen circumstances. In the unlikely event Mayo Clinic Laboratories must cancel or postpone this conference, Mayo Clinic Laboratories will refund the registration fee but is not responsible for any related costs, charges, or expenses to participants, including fees assessed by airline/travel/lodging agencies.
Fine print
All costs incurred by the registrant such as airline or hotel fees or penalties are the responsibility of the registrant.
Note: By participating in an onsite Mayo Clinic Laboratories Classical Hematology 2025 Conference event, you will be entering an area where livestreaming may occur. By entering Mayo Clinic's event premises, you consent to video and/or audio recording and their release for livestreaming purposes on the internet by Mayo Clinic during the Classical Hematology 2025 Conference event.
Poster session
The Mayo Clinic Classical Hematology Conference: Nonmalignant Hematology and Bleeding and Thrombotic Disorders course is accepting abstracts detailing original research dedicated to the field of classical hematology to be presented at this meeting. A poster session will take place on Oct. 25, 2025.
Submitted abstracts must include a focus on classical hematology and may include ongoing clinical trials in classical hematology, outcome studies, quality improvement or practice innovations, and interesting or challenging case reports. Abstracts will be peer-reviewed. At least one of the authors must register to attend the conference in person.
Submission deadline: August 1, 2025
Eligibility: Fellows, residents, medical students, advanced practice providers, nurses and lab technicians, and trainees are all eligible to submit an abstract.
Submission requirements
Review process: All abstracts will be reviewed based on their merit by a peer-reviewed process.
Additional details:
- Notification of acceptance will be sent to the primary author by August 29, 2025.
- At least one of the authors of the accepted abstract is required to present the poster at the course on Oct. 25, 2025. A discount code for registration will be provided as part of acceptance letters.
- Poster dimensions and other details will be available as part of acceptance letters.
- Authors may submit abstracts that have been published or presented previously at large Hematology meetings.
If you would like to submit an abstract for this year’s conference, please complete the following:
- Review eligibility and submission requirements.
- Complete the Abstract Registration.
For questions, please email stellmaker.allison@mayo.edu.
Exhibitors
If you would like to exhibit at this year’s conference, please complete the following:
- Download and review the Exhibitor Prospectus
- Download and sign the Exhibitor Agreement
- Complete the Exhibitor Registration
- Attach a copy of the signed Exhibitor Agreement during registration.
For questions, please email stellmaker.allison@mayo.edu.