Mayo Clinic Laboratories > Neurology > Neuromuscular disorders

Neuromuscular disorders

Answers From the Lab Test detects autoimmune neurology disorders linked to cancer
Video Neuropathy and Neuromuscular Gene Panel Update
Answers From the Lab Neuromuscular gene panel provides comprehensive analysis

Breakthrough discoveries that drive diagnosis

Neuromuscular diseases are a wide-ranging group of disorders affecting the peripheral nervous system (muscle, roots, plexus, nerves, motor neurons, neuromuscular junctions). A comprehensive menu of precision testing enables physicians to diagnose and manage patients with disorders such as myasthenia gravis, Lambert-Eaton syndrome, immune-mediated necrotizing myopathy, hereditary myopathy, and more. Our research, dedicated to learning more about these conditions, has led directly to the development of many specialized diagnostic tests.

Hereditary neuromuscular disorders Hereditary neuromuscular disorders
Hereditary neuromuscular disorders

Our distinctive approach to testing for genetic neuromuscular disorders uses phenotypic information to streamline diagnosis. Phenotype-specific panels enable targeted testing, improving diagnosis and minimizing uncertain results.

Myasthenia gravis and Lambert-Eaton syndrome Myasthenia gravis and Lambert-Eaton syndrome
Myasthenia gravis and Lambert-Eaton syndrome

Our reflexive approach to testing for myasthenia gravis and Lambert-Eaton syndrome optimizes diagnosis to expedite treatment. Consisting of upfront and confirmatory antibody testing, followed by automatic second-line testing, our diagnostic algorithm enables faster, more accurate answers for more patients.

Necrotizing autoimmune myopathy Necrotizing autoimmune myopathy
Necrotizing autoimmune myopathy

Our necrotizing autoimmune myopathy evaluation detects for HMGCR-IgG and SRP-IgG, which are the two most pertinent antibodies associated with the devastating condition.

News and updates

The latest

Multigene panel provides efficient ataxia diagnosis: Angela Pickart, M.S., CGC, and Emily Lauer, M.S., CGC

Angela Pickart, M.S., CGC, and Emily Lauer, M.S., CGC, explain how Mayo Clinic Laboratories' multigene panel helps identify the cause of hereditary ataxia. Precise diagnosis of this complex movement disorder helps guide patient treatment and family screening.

Learn more
Neuromuscular gene panel provides comprehensive analysis: Zhiyv (Neal) Niu, Ph.D., and Christopher Klein, M.D.

Zhiyv (Neal) Niu, Ph.D., and Christopher Klein, M.D., explain how Mayo Clinic Laboratories' updated neuromuscular gene panel informs diagnosis and treatment. The phenotype-based panel covers the complete list of neuromuscular genes and their variants.

Neuropathy and Neuromuscular Gene Panel Update

In this month's "Hot Topic," Christopher Klein, M.D., and Zhiyv (Neal) Niu, Ph.D., discuss how Mayo Clinic’s neuropathy and neuromuscular gene panels have enhanced patient care.

Myasthenia Gravis [Test in Focus]

Christopher Klein, M.D., discusses Mayo Clinic’s updated myasthenia gravis and Lambert-Eaton syndrome testing approach. Automatic reflex to second-line testing saves time and increases sensitivity and specificity to confirm diagnosis in patients with atypical presentation.

Improved Diagnosis of Necrotizing Autoimmune Myopathy by Combinatorial Immune Assays

This “Specialty Testing” webinar will discuss the diagnosis, pathological understanding, and current best treatment options for necrotizing autoimmune myopathy.

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