The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including featured abstracts and complete list of published studies and reviews.
Mayo Clinic researchers conducted a study to assess the efficacy of warfarin in the treatment of bioprosthetic valve thrombosis (BPVT) of surgically implanted valves. Fifty-two patients were enrolled in the study. Prosthesis positions were aortic in 31 patients, mitral in 17, pulmonary in 2, and tricuspid in 2. Positive responses (defined as a 50% reduction in prosthesis gradient) occurred in 43 patients within 11 weeks of anticoagulation with warfarin. Nine patients did not respond to warfarin, and these patients underwent surgical valve replacement, transcatheter valve replacement, and intervention. BPVT scores were calculated for 48 patients with good-quality echocardiographic images; 9 had BPVT scores of 2, and 39 had BPVTs score of 3. A BPVT score of 3 predicted a positive response to anticoagulation therapy with sensitivity of 88% and specificity of 93%. A trial of anticoagulation was effective in 83% of patients with suspected BPVT, and most patients responded within 3 months. BPVT score was predictive of response to therapy and should be considered during patient selection. The study was published in JACC Cardiovascular Interventions.