Mayo Clinic Laboratory and Pathology Research Roundup: April 3

By Kelley Luedke • April 3, 2017

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The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including featured abstracts and complete list of published studies and reviews.

Featured Abstract

Advancing Diagnostics to Address Antibacterial Resistance: The Diagnostics and Devices Committee of the Antibacterial Resistance Leadership Group

Diagnostics are a cornerstone of the practice of infectious diseases. However, various limitations frequently lead to unmet clinical needs. In most other domains, diagnostics focus on narrowly defined questions, provide readily interpretable answers, and use true gold standards for development. In contrast, infectious diseases diagnostics must contend with scores of potential pathogens, dozens of clinical syndromes, emerging pathogens, rapid evolution of existing pathogens and their associated resistance mechanisms, and the absence of gold standards in many situations. In spite of these challenges, the importance and value of diagnostics cannot be underestimated. Therefore, the Antibacterial Resistance Leadership Group has identified diagnostics as one of four major areas of emphasis. Herein, Mayo Clinic researchers provide an overview of that development, highlighting several examples where innovation in study design, content, and execution is advancing the field of infectious diseases diagnostics. The study was published in Clinical Infectious Diseases.

Published to PubMed This Week

• Prognostic Value of Soluble ST2 after Myocardial Infarction: A Community Perspective
  American Journal of Medicine
• TFEB-VEGFA (6p21.1) Co-Amplified Renal Cell Carcinoma: A Distinct Entity with Potential Implications for Clinical Management
  Modern Pathology
  
• Looking Under the Streetlight? A Framework for Differentiating Performance Measures by Level of Care in a Value-Based Payment Environment
  Academic Medicine
• Impact of Contaminating DNA in Whole Genome Amplification Kits Used for Metagenomic Shotgun Sequencing for Infection Diagnosis
  Journal of Clinical Microbiology
• Individual Patient-Level Meta-Analysis of the Performance of the Decipher Genomic Classifier in High-Risk Men After Prostatectomy to Predict Development of Metastatic Disease
  Journal of Clinical Microbiology
• Establishing Human Heart Chromium, Cobalt and Vanadium Concentrations by Inductively Coupled Plasma Mass Spectrometry
  Journal of Trace Elements in Medicine and Biology
• FLT3 Mutation Testing in Acute Myeloid Leukemia
  JAMA Oncology

Kelley Luedke

Kelley Luedke is a Marketing Channel Manager at Mayo Clinic Laboratories. She is the principle editor and writer of Insights and leads social media and direct marketing strategy. Kelley has worked at Mayo Clinic since 2013. Outside of work, you can find Kelley running, traveling, playing with her kitty, and exploring new foods.