Mayo Clinic Laboratory and Pathology Research Roundup: April 10

By Kelley Luedke • April 10, 2017

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The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including featured abstracts and complete list of published studies and reviews.

Featured Abstract

Thyroid Hormone Treatment among Pregnant Women with Subclinical Hypothyroidism: U.S. National Assessment

Mayo Clinic researchers conducted a study to estimate the effectiveness and safety of thyroid hormone treatment among pregnant women with subclinical hypothyroidism. Among 5405 pregnant women with subclinical hypothyroidism, 843 with a mean pre-treatment thyroid stimulating hormone (TSH) concentration of 4.8 mIU/L were treated with thyroid hormone and 4562 with a mean baseline TSH concentration of 3.3 mIU/L were not treated. Pregnancy loss was significantly less common among treated women than among untreated women. Compared with the untreated group, treated women had lower adjusted odds of pregnancy loss but higher odds of preterm delivery, gestational diabetes, and pre-eclampsia; other pregnancy related adverse outcomes were similar between the two groups. Thyroid hormone treatment was associated with decreased risk of pregnancy loss among women with subclinical hypothyroidism, especially those with pre-treatment TSH concentrations of 4.1-10 mIU/L. However, the increased risk of other pregnancy related adverse outcomes calls for additional studies evaluating the safety of thyroid hormone treatment in this patient population. The study was published in BMJ.

Published to PubMed This Week

• How I Treat Autoimmune Hemolytic Anemia
  Blood
• Predictors of Progression in Barrett's Esophagus with Low-Grade Dysplasia: Results from a Multicenter Prospective BE Registry
  American Journal of Gastroenterology
  
• A Possible Novel Prosthetic Joint Infection Pathogen, Mycoplasma salivarium, Identified by Metagenomic Shotgun Sequencing
  Clinical Infectious Diseases
• Intractable Epilepsy and Progressive Cognitive Decline in a Young Man
  JAMA Neurology
• WILD Syndrome is GATA2 Deficiency: A Novel Deletion in the GATA2 Gene
  Journal of Allergy and Clinical Immunology
• Monocytosis in Polycythemia Vera: Clinical and Molecular Correlates
  American Journal of Hematology
• Associations between Elevated Pre-treatment Serum Cytokines and Peripheral Blood Cellular Markers of Immunosuppression in Patients with Lymphoma
  American Journal of Hematology
• The Prevalence of Sleep Apnea in Type B Aortic Dissection: Implications for False Lumen Thrombosis
  Sleep
• Prognostic Relevance of Lymphocytopenia, Monocytopenia and Lymphocyte-to-Monocyte Ratio in Primary Myelodysplastic Syndromes: A Single Center Experience in 889 Patients
  Blood Cancer Journal
• Hemosiderotic Fibrolipomatous Tumor, Pleomorphic Hyalinizing Angiectatic Tumor, and Myxoinflammatory Fibroblastic Sarcoma: Related or Not?
  Advances in Anatomic Pathology
• A Successful Approach to Minimizing Attrition in Racial/Ethnic Minority, Low-Income Populations
  Contemporary Clinical Trials Communications
• Measuring the Impact of Ambulatory Red Blood Cell Transfusion on Home Functional Status: Study Protocol for a Pilot Randomized Controlled Trial
  Trials
• Role of the Common Fragile Sites in Cancers with a Human Papillomavirus Etiology
  Cytogenetic and Genome Research
• Acute Aortitis of the Ascending Aorta
  Interactive CardioVascular and Thoracic Surgery
• Gastrointestinal Bleeding from Metastatic Prostate Adenocarcinoma to the Stomach
  ACG Case Reports Journal
• Human Papillomavirus and the Development of Different Cancers
  Cytogenetic and Genome Research

Kelley Luedke

Kelley Luedke is a Marketing Channel Manager at Mayo Clinic Laboratories. She is the principle editor and writer of Insights and leads social media and direct marketing strategy. Kelley has worked at Mayo Clinic since 2013. Outside of work, you can find Kelley running, traveling, playing with her kitty, and exploring new foods.