The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including featured abstracts and complete list of published studies and reviews.
While it has been demonstrated that receipt of neoadjuvant chemotherapy (NAC) before radical cystectomy improves survival compared to radical cystectomy alone, the driving factor for this benefit may be from patients with ypT0 status at surgery. Meanwhile, the implications of having residual urothelial carcinoma of the bladder at radical cystectomy after neoadjuvant chemotherapy are less clear. Mayo Clinic researchers evaluated whether survival differed between patients with residual urothelial carcinoma of the bladder at radical cystectomy after NAC and stage-matched controls who underwent radical cystectomy alone. On surgical removal of the bladder, patients without residual bladder cancer after neoadjuvant chemotherapy have excellent survival outcomes. However, patients with residual cancer after neoadjuvant chemotherapy and surgery have worse outcomes compared to patients undergoing surgery alone. These patients should therefore be considered for additional treatments after surgery using newer agents while we await further research on predicting which patients will benefit from neoadjuvant chemotherapy before bladder removal for cancer. The study was published in European Urology.