Mayo Clinic Laboratory and Pathology Research Roundup: June 19

By Kelley Luedke • June 19, 2017

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The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including featured abstracts and complete list of published studies and reviews.

Featured Abstract

Single-Nephron Glomerular Filtration Rate in Healthy Adults

The glomerular filtration rate (GFR) assesses the function of all nephrons, and the single-nephron GFR assesses the function of individual nephrons. How the single-nephron GFR relates to demographic and clinical characteristics and kidney-biopsy findings in humans is unknown. Mayo Clinic researchers identified 1388 living kidney donors at the Mayo Clinic and the Cleveland Clinic who underwent a computed tomographic (CT) scan of the kidney with the use of contrast material and an iothalamate-based measurement of the GFR during donor evaluation and who underwent a kidney biopsy at donation. The mean single-nephron GFR was calculated as the GFR divided by the number of nephrons. Demographic and clinical characteristics and biopsy findings were correlated with the single-nephron GFR. Among healthy adult kidney donors, the single-nephron GFR was fairly constant with regard to age, sex, and height (if ≤190 cm). A higher single-nephron GFR was associated with certain risk factors for chronic kidney disease and certain kidney-biopsy findings. The study was published in the New England Journal of Medicine.

Published to PubMed This Week

• Occurrence of IgG4 in Esophageal Lichen Planus
  Clinical Gastroenterology and Hepatology
• Pembrolizumab-Induced Thyroiditis. Comprehensive Clinical Review and Insights into Underlying Involved Mechanisms
  Journal of Clinical Endocrinology & Metabolism
  
• The Almost-normal Liver Biopsy: Presentation, Clinical Associations, and Outcome
  American Journal of Surgical Pathology
• Long-term Follow-up of Chemoimmunotherapy with Rituximab, Oxaliplatin, Cytosine Arabinoside, Dexamethasone (ROAD) in Patients With Relapsed CD20+ B-Cell Non-Hodgkin Lymphoma: Results of a study of the Mayo Clinic Cancer Research Consortium (MCCRC) MC0485 Now Known as Academic and Community Cancer Research United (ACCRU)
  American Journal of Hematology
• Efficacy of the Oral mTORC1 Inhibitor Everolimus in Relapsed or Refractory Indolent Lymphoma
  American Journal of Hematology
• The Prognostic Relevance of Serum Lactate Dehydrogenase and Mild Bone Marrow Reticulin Fibrosis in Essential Thrombocythemia
  American Journal of Hematology
• Alterations in Cardiac Deformation, Timing of Contraction and Relaxation, and Early Myocardial Fibrosis Accompany the Apparent Recovery of Acute Stress-Induced (Takotsubo) Cardiomyopathy: An End to the Concept of Transience
  Journal of the American Society of Echocardiography
• Maximal Aortic Diameter Affects Outcome After Endovascular Repair of Abdominal Aortic Aneurysms
  Journal of Vascular Surgery
• Erratum to "Comparison of turnaround time and total cost of HIV testing before and after implementation of the 2014 CDC/APHL laboratory testing algorithm for diagnosis of HIV infection"
  Journal of Clinical Virology
• Is Axillary Surgery Beneficial for Patients with Adenoid Cystic Carcinoma of the Breast?
  Journal of Surgical Oncology
• Autosomal Dominant Distal Myopathy Due to a Novel ACTA1 Mutation
  Neuromuscular Disorders
• The North American Neuroendocrine Tumor Society Consensus Guidelines for Surveillance and Medical Management of Midgut Neuroendocrine Tumors
  Pancreas
• Lymphoma Classification Update: B-cell Non-Hodgkin Lymphomas
  Expert Review of Hematology
• C3 Glomerulonephritis with a Severe Crescentic Phenotype
  Pediatric Nephrology
• Effects of Primary and Recurrent Sacral Chordoma on the Motor and Nociceptive Function of Hindlimbs in Rats: An Orthotopic Spine Model
  Journal of Neurosurgery: Spine
• ACR Appropriateness Criteria: Permanent Source Brachytherapy for Prostate Cancer
  Brachytherapy
• Predicting Deletion of Chromosomal Arms 1p/19q in Low-Grade Gliomas from MR Images Using Machine Intelligence
  Journal of Digital Imaging
• Bordetella Parapertussis Outbreak in Southeastern Minnesota and the United States, 2014
  Medicine
• Prevention of Surgical Site Infections and Biofilms: Pharmacokinetics of Subcutaneous Cefazolin and Metronidazole in a Tumescent Lidocaine Solution
  Plastic and Reconstructive Surgery

Kelley Luedke

Kelley Luedke is a Marketing Channel Manager at Mayo Clinic Laboratories. She is the principle editor and writer of Insights and leads social media and direct marketing strategy. Kelley has worked at Mayo Clinic since 2013. Outside of work, you can find Kelley running, traveling, playing with her kitty, and exploring new foods.