Mayo Clinic Laboratory and Pathology Research Roundup: July 10

By Kelley Luedke • July 10, 2017

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The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including featured abstracts and complete list of published studies and reviews.

Featured Abstract

Association of Postoperative High-Sensitivity Troponin Levels with Myocardial Injury and 30-Day Mortality among Patients Undergoing Noncardiac Surgery

Little is known about the relationship between perioperative high-sensitivity troponin T (hsTnT) measurements and 30-day mortality and myocardial injury after noncardiac surgery (MINS). Mayo Clinic researchers conducted a study to determine the association between perioperative hsTnT measurements and 30-day mortality and potential diagnostic criteria for MINS (ie, myocardial injury due to ischemia associated with 30-day mortality). A modified Mazumdar approach (an iterative process) was used to determine if there were hsTnT thresholds associated with risk of death and had an adjusted hazard ratio (HR) of 3.0 or higher and a risk of 30-day mortality of 3% or higher. To determine potential diagnostic criteria for MINS, regression analyses ascertained if postoperative hsTnT elevations required an ischemic feature (eg, ischemic symptom or electrocardiography finding) to be associated with 30-day mortality. Among patients undergoing noncardiac surgery, peak postoperative hsTnT during the first 3 days after surgery was significantly associated with 30-day mortality. Elevated postoperative hsTnT without an ischemic feature was also associated with 30-day mortality. The study was published in JAMA.

Published to PubMed This Week

• Breast Cancer Risk and Progressive Histology in Serial Benign Biopsies
  Journal of the National Cancer Institute
• CAP/ACMG Proficiency Testing for Biochemical Genetics Laboratories: A Summary of Performance
  Genetics in Medicine
  
• A Man with Recurrent Ascites after Laparoscopic Cholecystectomy
  Clinical Chemistry
• The Evolution of Brachytherapy for Prostate Cancer
  Nature Reviews Urology
• Bile Acid Deficiency in Subgroup of Patients With Irritable Bowel Syndrome With Constipation Based on Biomarkers in Serum and Fecal Samples
  Clinical Gastroenterology and Hepatology
• Prefibrotic Versus Overtly Fibrotic Primary Myelofibrosis: Clinical, Cytogenetic, Molecular and Prognostic Comparisons
  British Journal of Haematology
• Endogenous Heat-Shock Protein Induction with or Without Radiofrequency Ablation or Cryoablation in Patients with Stage IV Melanoma
  Oncologist
• Effects of Cholecalciferol Supplementation on Serum and Urinary Vitamin D Metabolites and Binding Protein in HIV-Infected Youth
  Journal of Steroid Biochemistry and Molecular Biology
• Laboratory Diagnosis of Infective Endocarditis
  Journal of Clinical Microbiology
• Effects of Increasing Levothyroxine on Pregnancy Outcomes in Women with Uncontrolled Hypothyroidism
  Clinical Endocrinology
• Hypothalamo-Pituitary-Adrenal Axis After a Single Epidural Triamcinolone Injection
  Endocrine
• Intra-articular Injection of a Substance P Inhibitor Affects Gene Expression in a Joint Contracture Model
  Journal of Cellular Biochemistry
• Clinical-Pathologic Correlations in Voltage-Gated Kv1 Potassium Channel Complex-Subtyped Autoimmune Painful Polyneuropathy
  Muscle Nerve
• Central Nervous System Blastomycosis in Children: A Case Report and Review of the Literature
  Pediatric Infectious Disease Journal
• Histopathology of Parasitic Infections of the Lung
  Seminars Diagnostic Pathology
• A Severe Case of Congenital Thrombotic Thrombocytopenia Purpura Resulting From Compound Heterozygosity Involving a Novel ADAMTS13 Pathogenic Variant
  Journal of Pediatric Hematology/Oncology
• Primary Mucoepidermoid Carcinoma of the Lung with Prominent Clear Cells
  Proceedings (Baylor University. Medical Center)
• Abnormal Expression of Homeobox Genes and Transthyretin in C9ORF72 Expansion Carriers
  Neurology: Genetics

Kelley Luedke

Kelley Luedke is a Marketing Channel Manager at Mayo Clinic Laboratories. She is the principle editor and writer of Insights and leads social media and direct marketing strategy. Kelley has worked at Mayo Clinic since 2013. Outside of work, you can find Kelley running, traveling, playing with her kitty, and exploring new foods.