Mayo Clinic Laboratory and Pathology Research Roundup: July 17

By Kelley Luedke • July 17, 2017

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The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including featured abstracts and complete list of published studies and reviews.

Featured Abstract

Postoperative Stereotactic Radiosurgery Compared with Whole Brain Radiotherapy for Resected Metastatic Brain Disease: A Multicentre, Randomised, Controlled, Phase 3 Trial

Whole brain radiotherapy (WBRT) is the standard of care to improve intracranial control following resection of brain metastasis. However, stereotactic radiosurgery (SRS) to the surgical cavity is widely used in an attempt to reduce cognitive toxicity, despite the absence of high-level comparative data substantiating efficacy in the postoperative setting. Mayo Clinic researchers conducted a study to establish the effect of SRS on survival and cognitive outcomes compared with WBRT in patients with resected brain metastasis. The study found decline in cognitive function was more frequent with WBRT than with SRS and there was no difference in overall survival between the treatment groups. After resection of a brain metastasis, SRS radiosurgery should be considered one of the standards of care as a less toxic alternative to WBRT for this patient population. The study was published in Lancet Oncology.

Published to PubMed This Week

• TCR-CXCR4 Signaling Stabilizes Cytokine mRNA Transcripts via a PREX1-Rac1 Pathway: Implications for CTCL
  Blood
• United States and European Multicenter Prospective Study for the Analytical Performance and Clinical Validation of a Novel Sensitive Fully Automated Immunoassay for Calcitonin
  Clinical Chemistry
  
• Performance Characteristics of Serum C4 and FGF19 Measurements to Exclude the Diagnosis of Bile Acid Diarrhoea in IBS-Diarrhoea and Functional Diarrhoea
  Alimentary Pharmacology & Therapeutics
• Squamous Cell Carcinoma of the Tongue
  Mayo Clinic Proceedings
• 60-Year-Old Woman With Headache and Fatigue
  Mayo Clinic Proceedings
• Cytogenetic Findings in WHO-Defined Polycythaemia Vera and Their Prognostic Relevance
  British Journal of Haematology
• Long-Term Analysis of Phase II Studies of Single-Agent Lenalidomide in Relapsed/Refractory Mantle Cell Lymphoma
  American Journal of Hematology
• POEMS Syndrome: An Elusive Diagnosis
  American Journal of Hematology
• Patient-Reported Outcomes Can Be Used to Streamline Post-Total Hip Arthroplasty Follow-Up to High-Risk Patients
  Journal of Arthroplasty
• Soluble ST2 Does Not Change Cardiovascular Risk Prediction Compared to Cardiac Troponin T in Kidney Transplant Candidates
  PLoS One
• Oncologic Surveillance Following Radical Cystectomy: An Individualized Risk-Based Approach
  World Journal of Urology
• Histopathology of Fungal Diseases of the Lung
  Seminars in Diagnostic Pathology
• Histopathology of Viral Infections of the Lung
  Seminars in Diagnostic Pathology
• Development of a Real-Time PCR Method for Quantification of Prevotella Histicola From the Gut
  Anaerobe
• Proposal to Reclassify Ehrlichia muris as Ehrlichia muris subsp. muris subsp. nov. and Description of Ehrlichia muris subsp. eauclairensis subsp. nov., a Newly Recognized Tick-Borne Pathogen of Humans
  International Journal of Systematic and Evolutionary Microbiology
• Genital Rhabdomyoma of the Lower Female Genital Tract: A Study of 12 Cases With Molecular Cytogenetic Findings
  International Journal of Systematic and Evolutionary Microbiology
  
• A Rash with a Heavy Heart
  Echo Research and Practice

Kelley Luedke

Kelley Luedke is a Marketing Channel Manager at Mayo Clinic Laboratories. She is the principle editor and writer of Insights and leads social media and direct marketing strategy. Kelley has worked at Mayo Clinic since 2013. Outside of work, you can find Kelley running, traveling, playing with her kitty, and exploring new foods.