Mayo Clinic Laboratory and Pathology Research Roundup: Aug. 14
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The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including featured abstracts and complete list of published studies and reviews.
Featured Abstract
Human Gut-Derived Commensal Bacteria Suppress CNS Inflammatory and Demyelinating Disease
The human gut is colonized by a large number of microorganisms that support various physiologic functions. A perturbation in the healthy gut microbiome might lead to the development of inflammatory diseases, such as multiple sclerosis (MS). Therefore, gut commensals might provide promising therapeutic options for treating MS and other diseases. Mayo Clinic researchers report the identification of human gut-derived commensal bacteria, Prevotella histicola, which can suppress experimental autoimmune encephalomyelitis (EAE) in a human leukocyte antigen (HLA) class II transgenic mouse model. P. histicola suppresses disease through the modulation of systemic immune responses. P. histicola challenge led to a decrease in pro-inflammatory Th1 and Th17 cells and an increase in the frequencies of CD4+FoxP3+ regulatory T cells, tolerogenic dendritic cells, and suppressive macrophages. The study provides evidence that the administration of gut commensals may regulate a systemic immune response and may, therefore, have a possible role in treatment strategies for MS. The study was published in Cell Reports.
Published to PubMed This Week
- Undetectable Negative Tissue Transglutaminase IgA Antibodies Predict Mucosal Healing in Treated Coeliac Disease Patients
Alimentary Pharmacology & Therapeutics - Hepatocellular Carcinoma
Mayo Clinic Proceedings
- Dexamethasone, Rituximab and Cyclophosphamide for Relapsed and/or Refractory and Treatment-Naïve Patients with Waldenstrom Macroglobulinemia
British Journal of Haematology - The Prognostic Significance of Polyclonal Bone Marrow Plasma Cells in Patients with Relapsing Multiple Myeloma
American Journal of Hematology - Gender and Survival in Essential Thrombocythemia: A Two-Center Study of 1,494 Patients
American Journal of Hematology - Risk Factors and a Prognostic Model for Post-Splenectomy Survival in Myelofibrosis
American Journal of Hematology - Looking Under the Streetlight? A Framework for Differentiating Performance Measures by Level of Care in a Value-Based Payment Environment
Academic Medicine - CYP2D6 Phenotypes are Associated with Adverse Outcomes Related to Opioid Medications
Pharmacogenomics and Personalized Medicine - Pseudo-Monoclonal Gammopathy: a report of four cases.
Endocrinology Metabolism Clinics of North America - Previously Unreported in Women Galactosidase Alpha Pro409Ser Variant is Associated With Fabry Disease
Circulation: Cardiovascular Genetics - Hydrogen-Deuterium Exchange Mass Spectrometry Reveals Calcium Binding Properties and Allosteric Regulation of Downstream Regulatory Element Antagonist Modulator (DREAM)
Biochemistry - Performance Characteristics of a High-Sensitivity Cardiac Troponin Assay Using Plasma and Whole Blood Samples
Clinical Biochemistry - Long-Standing Crohn's Disease and its Implication on Anal Squamous Cell Cancer Management
International Journal of Colorectal Disease - Epithelioid Inflammatory Myofibroblastic Sarcoma of the Ovary With RANB2-ALK Fusion: Report of a Case
International Journal of Gynecological Pathology - INDIE-HFpEF (Inorganic Nitrite Delivery to Improve Exercise Capacity in Heart Failure With Preserved Ejection Fraction): Rationale and Design
Circulation: Heart Failure
