Mayo Clinic Laboratory and Pathology Research Roundup: Sept. 4

By Kelley Luedke • September 4, 2017

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The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including featured abstracts and complete list of published studies and reviews.

Featured Abstract

Individual Patient-Level Meta-Analysis of the Performance of the Decipher Genomic Classifier in High-Risk Men after Prostatectomy to Predict Development of Metastatic Disease

Mayo Clinic researchers conducted a study to perform the first meta-analysis of the performance of the genomic classifier test, Decipher, in men with prostate cancer postprostatectomy. Five studies were eligible for analysis, with a median follow-up of 8 years. Of the total cohort, 60.9%, 22.6%, and 16.5% of patients were classified by Decipher as low, intermediate, and high risk, respectively. The 10-year cumulative incidence metastases rates were 5.5%, 15.0%, and 26.7%, respectively, for the three risk classifications. Pooling the study-specific Decipher hazard ratios (HRs) across the five studies resulted in an HR of 1.52 per 0.1 unit. In multivariable analysis of individual patient data, adjusting for clinicopathologic variables, Decipher remained a statistically significant predictor of metastasis per 0.1 unit. The C-index for 10-year distant metastasis of the clinical model alone was 0.76; this increased to 0.81 with inclusion of Decipher. Based on the results, the genomic classifier test, Decipher, can independently improve prognostication of patients postprostatectomy, as well as within nearly all clinicopathologic, demographic, and treatment subgroups. Future study of how to best incorporate genomic testing in clinical decision-making and subsequent treatment recommendations is warranted. The review was published in Journal of Clinical Oncology.

Published to PubMed This Week

• C4 Nephritic Factors in C3 Glomerulopathy: A Case Series
  American Journal of Kidney Diseases
• Distinguishing between Hepatic Inflammation and Fibrosis with MR Elastography
  Radiology
  
• Alterations in Cardiac Deformation, Timing of Contraction and Relaxation, and Early Myocardial Fibrosis Accompany the Apparent Recovery of Acute Stress-Induced (Takotsubo) Cardiomyopathy: An End to the Concept of Transience
  Journal of the American Society of Echocardiography
• Tissue-Based Associations of Mammographic Breast Density with Breast Stem Cell Markers
  Breast Cancer Research
• High Sensitivity Blood-Based M-Protein Detection in sCR Patients with Multiple Myeloma
  Blood Cancer Journal
• Vitamin D Insufficiency is Associated with an Increased Risk of Early Clinical Failure in Follicular Lymphoma
  Blood Cancer Journal
• Relapse Rates With Surgery Alone in Human Papillomavirus-Related Intermediate- and High-Risk Group Oropharynx Squamous Cell Cancer: A Multi-Institutional Review
  International Journal of Radiation Oncology Biology Physics
• Clinicopathologic Discrepancies in a Population-Based Incidence Study of Parkinsonism in Olmsted County: 1991-2010
  Movement Disorders
• 32 Doses of Bortezomib for Desensitization Is Not Well Tolerated and Is Associated With Only Modest Reductions in Anti-HLA Antibody
  Transplantation
• Incompatible Type A Plasma Transfusion in Patients Requiring Massive Transfusion Protocol: Outcomes of an Eastern Association for the Surgery of Trauma Multicenter Study
  Journal of Trauma and Acute Care Surgery
• Squamoid Morules in the Pseudoinvasive Foci of Colonic Polyp Morphologically Mimic Invasive Carcinoma
  Human Pathology
• Comparison of Bioavailability of Single-Dose Extended-Release Venlafaxine Capsules in Obese Patients Before and After Gastric Bypass Surgery
  Pharmacotherapy
• The Effects of Beginning Population Based PSA Screening at Age 40
  Urology
• Renal Dysfunction: How to Think About That in Acute Coronary Syndromes
  Current Cardiology Reports
• An Unusual Case of Acute Myeloid Leukemia Cell Infiltration of the Renal Allograft: A Case Report and Review of Literature
  Transplant Proceedings
• Plexogenic Pulmonary Hypertension Associated with POEMS Syndrome.
  Respiratory Medicine Case Reports
• Comparison of Standardized Cytomegalovirus (CMV) Viral Load Thresholds in Whole Blood and Plasma of Solid Organ and Hematopoietic Stem Cell Transplant Recipients with CMV Infection and Disease
  Open Forum Infectious Diseases

Kelley Luedke

Kelley Luedke is a Marketing Channel Manager at Mayo Clinic Laboratories. She is the principle editor and writer of Insights and leads social media and direct marketing strategy. Kelley has worked at Mayo Clinic since 2013. Outside of work, you can find Kelley running, traveling, playing with her kitty, and exploring new foods.