Mayo Clinic Laboratory and Pathology Research Roundup: Dec. 11

By Kelley Luedke • December 11, 2017

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The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including featured abstracts and complete list of published studies and reviews.

Featured Abstract

Association Between Microinfarcts and Blood Pressure Trajectories

Cerebral microinfarcts are associated with increased risk of cognitive impairment and may have different risk factors than macroinfarcts. Subcortical microinfarcts are associated with declining blood pressure. Mayo Clinic researchers conducted a study to investigate blood pressure slopes as a risk factor for microinfarcts in elderly individuals. The study found the presence of cerebral microinfarcts using blood pressure slopes. Based on the results, subcortical microinfarcts were associated with declining blood pressure. Future studies should investigate whether declining blood pressure leads to subcortical microinfarcts or whether subcortical microinfarcts are a factor leading to declining blood pressure. The study was published in JAMA Neurology.

Published to PubMed This Week

• • C4 Nephritic Factors in C3 Glomerulopathy: A Case Series
    American Journal of Kidney Diseases
  • Establishing and Characterizing Patient-Derived Xenografts Using Pre-Chemotherapy Percutaneous Biopsy and Post-Chemotherapy Surgical Samples From a Prospective Neoadjuvant Breast Cancer Study
    Breast Cancer Research
  • Personal Viewpoint: The Bridge Between Transplantation and Regenerative Medicine. Beginning a New Banff Classification of Tissue Engineering Pathology
    American Journal of Transplantation
  • Splanchnic Vein Thrombosis in Patients with Myeloproliferative Neoplasms: The Mayo Clinic Experience with 84 Consecutive Cases
    American Journal of Hematology
  • A Path to Understanding Autoimmune GFAP Astrocytopathy
    European Journal of Neurology
  • Squamoid Morules in the Pseudoinvasive Foci of Colonic Polyp Morphologically Mimic Invasive Carcinoma
    Human Pathology
  • Isolated Acute Terminal Ileitis Without Preexisting Inflammatory Bowel Disease Rarely Progresses to Crohn's Disease
    Digestive Diseases and Sciences
  • Immunophenotypic and Laboratory Features of t(11;14)(q13;q32)-Positive Plasma Cell Neoplasms
    Leukemia & Lymphoma
  • Genetic Variation in Statin Intolerance and a Possible Protective Role for UGT1A1
    Pharmacogenomics
  • Red Tattoo Related Mycosis Fungoides-like CD8⁺ Pseudolymphoma
    Journal of Cutaneous Pathology
  • Diagnostic Testing for Zika: Observing Rapid Translation During a Public Health Emergency
    Clinical and Translational Science
  • Optic Disc Edema in Glial Fibrillary Acidic Protein Autoantibody-Positive Meningoencephalitis
    Journal of Neuro-Ophthalmology

Kelley Luedke

Kelley Luedke is a Marketing Channel Manager at Mayo Clinic Laboratories. She is the principle editor and writer of Insights and leads social media and direct marketing strategy. Kelley has worked at Mayo Clinic since 2013. Outside of work, you can find Kelley running, traveling, playing with her kitty, and exploring new foods.