Mayo Clinic Laboratory and Pathology Research Roundup: Dec. 18

The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including featured abstracts and complete list of published studies and reviews.

Featured Abstract

Different Mutational Rates and Mechanisms in Human Cells at Pregastrulation and Neurogenesis

Somatic mosaicism in the human brain may alter function of individual neurons. Mayo Clinic researchers analyzed genomes of single cells from the forebrains of three human fetuses (15 to 21 weeks post-conception) using clonal cell populations. They detected 200-400 single nucleotide variations (SNVs) per cell. SNV patterns resembled those found in cancer cell genomes, indicating a role of background mutagenesis in cancer. SNVs with a frequency of less than 2% in brain were shared with the spleen, revealing a pregastrulation origin. Researchers reconstructed cell lineages for the first five post-zygotic cleavages and calculated a mutation rate of approximately 1.3 per division per cell. Later in development, during neurogenesis, the mutation spectrum shifted toward oxidative damage and the mutation rate increased. Both neurogenesis and early embryogenesis exhibit drastically more mutagenesis than adulthood. The study was published in Science.

Published to PubMed This Week

Kelley Luedke

Kelley Luedke is a Marketing Channel Manager at Mayo Clinic Laboratories. She is the principle editor and writer of Insights and leads social media and direct marketing strategy. Kelley has worked at Mayo Clinic since 2013. Outside of work, you can find Kelley running, traveling, playing with her kitty, and exploring new foods.