The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including featured abstracts and complete list of published studies and reviews.
Mayo Clinic researchers hypothesized that pulmonary venous hypertension in heart failure leads to predominate remodeling of pulmonary veins and that the severity of venous remodeling is associated with the severity of pulmonary hypertension in heart failure. Based on study results, researchers found that in heart failure, pulmonary hypertension is associated with global pulmonary vascular remodeling but the severity of pulmonary hypertension correlates most strongly with venous and small IV intimal thickening, similar to the pattern observed in primary pulmonary veno-occlusive disease. These findings expand our understanding of the pathobiology of pulmonary hypertension in heart failure. The study was published in Circulation.