Mayo Clinic Laboratory and Pathology Research Roundup: Jan. 29

By Kelley Luedke • January 29, 2018

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The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including featured abstracts and complete list of published studies and reviews.

Featured Abstract

Pathways Impacted by Genomic Alterations in Pulmonary Carcinoid Tumors

Pulmonary carcinoid tumors account for up to 5% of all lung malignancies in adults, comprise 30% of all carcinoid malignancies, and are defined histologically as typical carcinoid and atypical carcinoid tumors. The role of specific genomic alterations in the pathogenesis of pulmonary carcinoid tumors remains poorly understood. Mayo Clinic researchers sought to identify genomic alterations and pathways that are deregulated in these tumors to find novel therapeutic targets for pulmonary carcinoid tumors. They performed integrated genomic analysis of carcinoid tumors comprising whole genome and exome sequencing, mRNA expression profiling, and SNP genotyping of specimens from normal lung, typical, and atypical carcinoid, and small cell lung carcinoma to fully represent the lung neuroendocrine tumor spectrum. The study identified mutated genes affecting cancer relevant pathways and biological processes that could provide opportunities for developing targeted therapies for pulmonary carcinoid tumors. The study was published in Clinical Cancer Research.

Published to PubMed This Week

• • Coronary Embolus: An Underappreciated Cause of Acute Coronary Syndromes
    JACC: Cardiovascular Interventions
  • EZH2 Mutations in Chronic Myelomonocytic Leukemia Cluster with ASXL1 Mutations and Their Co-Occurrence is Prognostically Detrimental
    Blood Cancer Journal
  • Niche Point-of-Care Endocrine Testing - Reviews of Intraoperative Parathyroid Hormone and Cortisol Monitoring
    Critical Reviews in Clinical Laboratory Sciences
  • Gene Expression Signatures Characterized by Longitudinal Stability and Interindividual Variability Delineate Baseline Phenotypic Groups with Distinct Responses to Immune Stimulation
    Journal of Immunology
  • Evaluation of Non-Tissue Culture- <i>versus</i> Tissue Culture-Treated Microplates for Oritavancin Susceptibility Testing
    Journal of Clinical Microbiology
  • Aggressive Variants of Papillary Thyroid Carcinoma: Hobnail, Tall Cell, Columnar, and Solid
    Advances in Anatomic Pathology
  • Parasitic Infections of the Skin and Subcutaneous Tissues
    Advances in Anatomic Pathology
  • Ki67 Proliferative Index in Carcinoid Tumors Involving Ovary
    Endocrine Pathology

Kelley Luedke

Kelley Luedke is a Marketing Channel Manager at Mayo Clinic Laboratories. She is the principle editor and writer of Insights and leads social media and direct marketing strategy. Kelley has worked at Mayo Clinic since 2013. Outside of work, you can find Kelley running, traveling, playing with her kitty, and exploring new foods.